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    Kif2b kinesin family member 2B [ Mus musculus (house mouse) ]

    Gene ID: 73470, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kif2bprovided by MGI
    Official Full Name
    kinesin family member 2Bprovided by MGI
    Primary source
    MGI:MGI:1920720
    See related
    Ensembl:ENSMUSG00000046755 AllianceGenome:MGI:1920720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700063D03Rik
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including metaphase plate congression; microtubule depolymerization; and regulation of chromosome segregation. Predicted to act upstream of or within cell division. Predicted to be located in intercellular bridge; mitotic spindle; and nucleolus. Predicted to be part of kinesin complex. Predicted to be active in centrosome; microtubule; and spindle. Orthologous to human KIF2B (kinesin family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    See Kif2b in Genome Data Viewer
    Location:
    11 D; 11 56.1 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (91466112..91468381, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (91575286..91577555, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930405D11 gene Neighboring gene STARR-seq mESC enhancer starr_30416 Neighboring gene STARR-seq mESC enhancer starr_30417 Neighboring gene STARR-seq mESC enhancer starr_30418 Neighboring gene STARR-seq mESC enhancer starr_30419 Neighboring gene STARR-seq mESC enhancer starr_30420 Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene STARR-seq mESC enhancer starr_30422 Neighboring gene STARR-seq mESC enhancer starr_30425 Neighboring gene STARR-seq mESC enhancer starr_30426 Neighboring gene STARR-seq mESC enhancer starr_30427 Neighboring gene STARR-seq mESC enhancer starr_30428 Neighboring gene predicted gene, 38950 Neighboring gene STARR-seq mESC enhancer starr_30429 Neighboring gene STARR-seq mESC enhancer starr_30430 Neighboring gene STARR-seq mESC enhancer starr_30431 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene ribosomal protein L15 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC118316

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028547.3 → NP_082823.1  kinesin-like protein KIF2B

      See identical proteins and their annotated locations for NP_082823.1

      Status: VALIDATED

      Source sequence(s)
      AL662779
      Consensus CDS
      CCDS36281.1
      UniProtKB/Swiss-Prot
      Q8C0N1
      UniProtKB/TrEMBL
      A2RSC8
      Related
      ENSMUSP00000058084.5, ENSMUST00000061019.6
      Conserved Domains (2) summary
      cd01367
      Location:213 → 541
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:219 → 542
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      91466112..91468381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0N1.1 GenPept UniProtKB/Swiss-Prot:Q8C0N1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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