U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ICL1 isocitrate lyase 1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856794, updated on 1-Aug-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    ICL1
    Gene description
    isocitrate lyase 1
    Primary source
    FungiDB:YER065C
    Locus tag
    YER065C
    See related
    SGD:S000000867; AllianceGenome:SGD:S000000867; VEuPathDB:YER065C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables isocitrate lyase activity. Involved in glyoxylate cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ICL1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (285241..286914, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Tho1p Neighboring gene Vhr2p Neighboring gene tRNA-Ser Neighboring gene Rrt13p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structural insights into the targeting specificity of ubiquitin ligase for S. cerevisiae isocitrate lyase but not C. albicans isocitrate lyase. Hiragi K, et al. J Struct Biol, 2021 Sep. PMID 34033899
    2. Isocitrate lyase of the yeast Kluyveromyces lactis is subject to glucose repression but not to catabolite inactivation. López ML, et al. Curr Genet, 2004 Jan. PMID 14569415
    3. The purification and properties of yeast isocitric lyase. OLSON JA. J Biol Chem, 1959 Jan. PMID 13610881
    4. PTS1-independent targeting of isocitrate lyase to peroxisomes requires the PTS1 receptor Pex5p. Parkes JA, et al. Mol Membr Biol, 2003 Jan-Mar. PMID 12745927
    5. A 27 kDa protein binds to a positive and a negative regulatory sequence in the promoter of the ICL1 gene from Saccharomyces cerevisiae. Ordiz I, et al. Biochem J, 1998 Jan 15. PMID 9425123, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isocitrate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isocitrate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isocitrate lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylisocitrate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glyoxylate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glyoxylate cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monocarboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    isocitrate lyase 1
    NP_010987.3
    • Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      285241..286914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178956.3 → NP_010987.3  TPA: isocitrate lyase 1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010987.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLX0, P28240
      UniProtKB/TrEMBL
      A6ZR19, B3LRI2, C7GTD3, C8Z771, G2WCV4
      Conserved Domains (1) summary
      pfam00463
      Location:22 → 550
      ICL; Isocitrate lyase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28240.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools