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    YPT6 Rab family GTPase YPT6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850966, updated on 1-Aug-2024

    Summary

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    Gene symbol
    YPT6
    Gene description
    Rab family GTPase YPT6
    Primary source
    FungiDB:YLR262C
    Locus tag
    YLR262C
    See related
    SGD:S000004252; AllianceGenome:SGD:S000004252; VEuPathDB:YLR262C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity. Involved in several processes, including Golgi vesicle transport; cytoplasm to vacuole transport by the Cvt pathway; and protein localization to phagophore assembly site. Located in cis-Golgi network and cytosol. Orthologous to several human genes including RAB6A (RAB6A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YPT6 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (668244..668891, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene chaperone ATPase HSP60 Neighboring gene sphinganine kinase LCB5 Neighboring gene Vps63p Neighboring gene Tma7p Neighboring gene Red1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical characterization of Gyp6p, a Ypt/Rab-specific GTPase-activating protein from yeast. Will E, et al. J Biol Chem, 2001 Apr 13. PMID 11278907
    2. A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family. Strom M, et al. Nature, 1993 Feb 25. PMID 8441469
    3. Characterization of MYR1, a dosage suppressor of YPT6 and RIC1 deficient mutants. Georgiev A, et al. Curr Genet, 2008 Apr. PMID 18327588
    4. Mutations of the SM protein Sly1 resulting in bypass of GTPase requirement in vesicular transport are confined to a short helical region. Li Y, et al. FEBS Lett, 2007 Dec 11. PMID 18036347
    5. Inhibition of sodium/proton exchange by a Rab-GTPase-activating protein regulates endosomal traffic in yeast. Ali R, et al. J Biol Chem, 2004 Feb 6. PMID 14610088

    See all (150) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ypt6 and Vps1 (vacuolar sorting protein-1, a dynamin homolog in yeast) facilitate endosome-to-the trans-Golgi Network traffic pathways with their GTPase activity.
      Title: Yeast dynamin and Ypt6 function in parallel for the endosome-to-Golgi retrieval of Snc1.
    2. Through this screen, we were able to confirm several membrane traffic and autophagy regulators that have novel relationships with Arl1 and Ypt6 during autophagy
      Title: A High Copy Suppressor Screen for Autophagy Defects in Saccharomyces arl1Δ and ypt6Δ Strains.
    3. These results suggest that the GTP-binding activity of Ypt6p is necessary for intra-Golgi trafficking and protein recycling in the early Golgi compartment.
      Title: Analysis of subcellular localization and function of the yeast Rab6 homologue, Ypt6p, using a novel amino-terminal tagging strategy.
    4. results suggest partially overlapping functions of the GTPases in resistance to various stress factors, with Ypt6 being more efficient under physiological conditions and Arl1 more versatile when overexpressed
      Title: Comparison of the influence of small GTPases Arl1 and Ypt6 on yeast cells' tolerance to various stress factors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to phagophore assembly site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, vesicle recycling within Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rab family GTPase YPT6
    NP_013363.1
    • Rab family GTPase; required for endosome-to-Golgi, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; temporarily at the Golgi, dissociating into the cytosol on arrival of the late Golgi GTPase Ypt32p; Golgi-localized form is GTP bound, while cytosolic form is GDP-bound; required for delivery of Atg9p to the phagophore assembly site during autophagy under heat stress, with Ypt6p for starvation induced autophagy and for the CVT pathway; homolog of mammalian Rab6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      668244..668891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182149.1 → NP_013363.1  TPA: Rab family GTPase YPT6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYQ8, Q99260
      UniProtKB/TrEMBL
      A7A1E2, B3RHE4, B5VNH4, C7GQX9, C8ZDM5, N1NZW8
      Conserved Domains (1) summary
      cd01861
      Location:11 → 173
      Rab6; Rab GTPase family 6 (Rab6)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99260.1

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