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    SLS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850830, updated on 11-Sep-2024

    Summary

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    Official Symbol
    SLS1
    Primary source
    SGD:S000004129
    Locus tag
    YLR139C
    See related
    AllianceGenome:SGD:S000004129; FungiDB:YLR139C; VEuPathDB:YLR139C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in aerobic respiration and mitochondrial translation. Located in mitochondrial inner membrane and mitochondrial nucleoid. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (421542..423473, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene Nha1p Neighboring gene Rrn5p Neighboring gene proline dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SLS1, a new Saccharomyces cerevisiae gene involved in mitochondrial metabolism, isolated as a syntheticlethal in association with an SSM4 deletion. Rouillard JM, et al. Mol Gen Genet, 1996 Oct 28. PMID 8917313
    2. Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis. Rodeheffer MS, et al. J Biol Chem, 2003 May 16. PMID 12637560, Free PMC Article
    3. Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression. Bryan AC, et al. Genetics, 2002 Jan. PMID 11805046, Free PMC Article
    4. Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purification. Markov DA, et al. Yeast, 2009 Aug. PMID 19536766, Free PMC Article
    5. Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Chen XJ, et al. Science, 2005 Feb 4. PMID 15692048

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sls1p
    NP_013240.1
    • Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      421542..423473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182026.1 → NP_013240.1  TPA: Sls1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013240.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYD4, P42900, Q6B228
      UniProtKB/TrEMBL
      A7A138, B3LTA0, B5VN69, C7GMJ1, C8ZDA8, N1NYA1
      Conserved Domains (1) summary
      pfam14611
      Location:146 → 343
      SLS; Mitochondrial inner-membrane-bound regulator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42900.1

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