AAT1 aspartate transaminase AAT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: AAT1
Official Full Name: aspartate transaminase AAT1
Primary source: SGD:S000001589
Locus tag: YKL106W
See related: AllianceGenome:SGD:S000001589; FungiDB:YKL106W; VEuPathDB:YKL106W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Involved in alpha-amino acid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See AAT1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (237536..238891)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secondary inactivation of Aat1 contributes to the amplification of the respiratory defect observed in Deltayfh1 cells.
Title: Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in alpha-amino acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in aspartate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aspartate transaminase AAT1

NP_012816.1

EC 2.6.1.1

Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

237536..238891

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179672.1 → NP_012816.1 TPA: aspartate transaminase AAT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012816.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXI2, Q01802

UniProtKB/TrEMBL

A6ZZL1, B5VM51, G2WHS8, N1P7Q4

Conserved Domains (1) summary

COG1448
Location:21 → 445

TyrB; Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]