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    SSH4 Ssh4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853735, updated on 1-Aug-2024

    Summary

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    Gene symbol
    SSH4
    Gene description
    Ssh4p
    Primary source
    FungiDB:YKL124W
    Locus tag
    YKL124W
    See related
    SGD:S000001607; AllianceGenome:SGD:S000001607; VEuPathDB:YKL124W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MLF4
    Summary
    Enables ubiquitin ligase-substrate adaptor activity. Involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SSH4 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (210593..212332)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase YPK1 Neighboring gene rDNA-binding RNA polymerase I transcriptional factor Neighboring gene signal recognition particle subunit SRP21 Neighboring gene Dgr2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The immunosuppressive drug leflunomide affects mating-pheromone response and sporulation by different mechanisms in Saccharomyces cerevisiae. Fujimura H. FEMS Microbiol Lett, 2000 Oct 1. PMID 11004400
    2. A selective transmembrane recognition mechanism by a membrane-anchored ubiquitin ligase adaptor. Arines FM, et al. J Cell Biol, 2021 Jan 4. PMID 33351099, Free PMC Article
    3. TORC1 regulates vacuole membrane composition through ubiquitin- and ESCRT-dependent microautophagy. Yang X, et al. J Cell Biol, 2020 Mar 2. PMID 32045480, Free PMC Article
    4. Molecular cloning of Saccharomyces cerevisiae MLF4/SSH4 gene which confers the immunosuppressant leflunomide resistance. Fujimura H. Biochem Biophys Res Commun, 1998 May 19. PMID 9610367
    5. Ubiquitin-dependent lysosomal membrane protein sorting and degradation. Li M, et al. Mol Cell, 2015 Feb 5. PMID 25620559

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ssh4-Rsp5 quality control system clears membrane proteins mistargeted to the vacuole membrane.
      Title: Rsp5 Ubiquitin ligase-mediated quality control system clears membrane proteins mistargeted to the vacuole membrane.
    2. Ear1p/Ssh4p recruit Rsp5p and assist it in its function at multivesicular bodies by directing the ubiquitylation of specific cargoes.
      Title: Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies.
    3. model in which Ssh4, Rcr2, and presumably Rcr1, function within the endosome-vacuole trafficking pathway, where they affect events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane
      Title: Ssh4, Rcr2 and Rcr1 affect plasma membrane transporter activity in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ssh4p
    NP_012798.1
    • Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      210593..212332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179690.1 → NP_012798.1  TPA: Ssh4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012798.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZZJ6, D6VX71, P32343
      UniProtKB/TrEMBL
      G2WHR3, N1P0R7
      Conserved Domains (1) summary
      cl02614
      Location:199 → 341
      SPRY; SPRY domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32343.2

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