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    CAB4 putative pantetheine-phosphate adenylyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853194, updated on 29-Jun-2024

    Summary

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    Gene symbol
    CAB4
    Gene description
    putative pantetheine-phosphate adenylyltransferase
    Primary source
    FungiDB:YGR277C
    Locus tag
    YGR277C
    See related
    SGD:S000003509; AllianceGenome:SGD:S000003509; VEuPathDB:YGR277C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Involved in coenzyme A biosynthetic process. Located in cytoplasm and nucleus. Part of CoA-synthesizing protein complex. Used to study cancer. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia. Orthologous to human COASY (Coenzyme A synthase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CAB4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1045644..1046561, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rtt102p Neighboring gene Rnh70p Neighboring gene U2-type spliceosomal complex subunit CWC22 Neighboring gene putative family 17 glucosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. Olzhausen J, et al. FEMS Yeast Res, 2013 Sep. PMID 23789928
    2. Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Olzhausen J, et al. Curr Genet, 2009 Apr. PMID 19266201
    3. Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway. Olzhausen J, et al. Appl Microbiol Biotechnol, 2021 Oct. PMID 34491400, Free PMC Article
    4. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. Daugherty M, et al. J Biol Chem, 2002 Jun 14. PMID 11923312
    5. Cell Lysate Microarray for Mapping the Network of Genetic Regulators for Histone Marks. Cheng L, et al. Mol Cell Proteomics, 2018 Sep. PMID 29871872, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantetheine-phosphate adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantetheine-phosphate adenylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coenzyme A biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in coenzyme A biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CoA-synthesizing protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative pantetheine-phosphate adenylyltransferase
    NP_011793.3
    • Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; involved in histone acylation; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT) and by human COASY

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1045644..1046561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181406.3 → NP_011793.3  TPA: putative pantetheine-phosphate adenylyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011793.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV54, P53332
      UniProtKB/TrEMBL
      A0A8H8UL07, A6ZUT3, B3LHW7, C7GNF8, G2WF00, N1P9Z7
      Conserved Domains (1) summary
      cd02164
      Location:144 → 288
      PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53332.1

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