BUD16 putative pyridoxal kinase BUD16 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: BUD16
Gene description: putative pyridoxal kinase BUD16
Primary source: FungiDB:YEL029C
Locus tag: YEL029C
See related: SGD:S000000755; AllianceGenome:SGD:S000000755; VEuPathDB:YEL029C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable pyridoxal kinase activity. Involved in pyridoxal phosphate biosynthetic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Orthologous to human PDXK (pyridoxal kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BUD16 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (96858..97796, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The most potent novel gross chromosomal rearrangements suppressor identified is BUD16, the gene coding for yeast pyridoxal kinase (Pdxk), a key enzyme in the metabolism of pyridoxal 5' phosphate (PLP), the biologically active form of vitamin B6.
Title: A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pyridoxal kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal kinase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal kinase activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in pyridoxal 5'-phosphate salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyridoxal 5'-phosphate salvage	IEA Inferred from Electronic Annotation more info
involved_in pyridoxal phosphate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pyridoxal phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitamin B6 metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putative pyridoxal kinase BUD16

NP_010885.1

EC 2.7.1.35

Putative pyridoxal kinase; a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; localizes to cytosol and peroxisomes; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

96858..97796 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178844.1 → NP_010885.1 TPA: putative pyridoxal kinase BUD16 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010885.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLM0, P39988

UniProtKB/TrEMBL

A0A8H8ULI5, A6ZQS0, B3LRY7, B5VHA7, C7GX14, C8Z6W8, G2WCK3, N1P5A7

Conserved Domains (1) summary

COG2240
Location:2 → 303

PdxK; Pyridoxal/pyridoxine/pyridoxamine kinase [Coenzyme transport and metabolism]