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    AIM7 Aim7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851635, updated on 29-Jun-2024

    Summary

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    Gene symbol
    AIM7
    Gene description
    Aim7p
    Primary source
    FungiDB:YDR063W
    Locus tag
    YDR063W
    See related
    SGD:S000002470; AllianceGenome:SGD:S000002470; VEuPathDB:YDR063W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GMF1
    Summary
    Predicted to enable Arp2/3 complex binding activity. Involved in actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Located in actin cortical patch. Orthologous to several human genes including GMFB (glia maturation factor beta). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See AIM7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (578663..579112)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene serine C-palmitoyltransferase LCB2 Neighboring gene ribosomal 40S subunit protein S13 Neighboring gene Rrg1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation. Gandhi M, et al. Curr Biol, 2010 May 11. PMID 20362448, Free PMC Article
    2. Combinatorial genetic analysis of a network of actin disassembly-promoting factors. Ydenberg CA, et al. Cytoskeleton (Hoboken), 2015 Jul. PMID 26147656, Free PMC Article
    3. GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism. Ydenberg CA, et al. Curr Biol, 2013 Jun 17. PMID 23727094, Free PMC Article
    4. GMF is an evolutionarily developed Adf/cofilin-super family protein involved in the Arp2/3 complex-mediated organization of the actin cytoskeleton. Nakano K, et al. Cytoskeleton (Hoboken), 2010 Jun. PMID 20517925
    5. Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF. Guo S, et al. Nat Commun, 2018 Jul 24. PMID 30042427, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Arp2/3 complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament debranching IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament debranching IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament debranching IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aim7p
    NP_010348.1
    • Protein that interacts with Arp2/3 complex; interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      578663..579112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180371.1 → NP_010348.1  TPA: Aim7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010348.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS49, Q12156
      UniProtKB/TrEMBL
      A0A8H8UMY0, A6ZY28, B3LGK7, C8Z4Y2, G2WAG7, N1P4L3
      Conserved Domains (1) summary
      cl15697
      Location:7 → 136
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12156.1

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