IRA1 GTPase-activating protein IRA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: IRA1
Gene description: GTPase-activating protein IRA1
Primary source: FungiDB:YBR140C
Locus tag: YBR140C
See related: SGD:S000000344; AllianceGenome:SGD:S000000344; VEuPathDB:YBR140C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GLC1; PPD1
Summary: Enables GTPase activator activity. Involved in several processes, including negative regulation of Ras protein signal transduction; positive regulation of GTPase activity; and regulation of adenylate cyclase activity. Located in membrane. Used to study neurofibromatosis and neurofibromatosis 1. Human ortholog(s) of this gene implicated in autistic disorder; hematologic cancer (multiple); nervous system cancer (multiple); neurofibromatosis (multiple); and neurofibromatosis-Noonan syndrome. Orthologous to several human genes including NF1 (neurofibromin 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Roles of two protein phosphatases, Reg1-Glc7 and Sit4, and glycogen synthesis in regulation of SNF1 protein kinase.
Title: Roles of two protein phosphatases, Reg1-Glc7 and Sit4, and glycogen synthesis in regulation of SNF1 protein kinase.
Ira1 and Ira2 affect glycerophosphoinositol production and transport.
Title: Neurofibromin homologs Ira1 and Ira2 affect glycerophosphoinositol production and transport in Saccharomyces cerevisiae.
Gpb1/2 bind to a conserved C-terminal domain of Ira1/2, and loss of Gpb1/2 results in a destabilization of Ira1 and Ira2, leading to elevated levels of Ras2-GTP and unbridled cAMP-PKA signaling.
Title: The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	HDA more info	PubMed

NP_009698.3

GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis

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The following sections contain reference sequences that belong to a specific genome build. Explain