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    YPR127W pyridoxine 4-dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856245, updated on 17-May-2024

    Summary

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    Gene symbol
    YPR127W
    Gene description
    pyridoxine 4-dehydrogenase
    Primary source
    FungiDB:YPR127W
    Locus tag
    YPR127W
    See related
    SGD:S000006331; AllianceGenome:SGD:S000006331; VEuPathDB:YPR127W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable aldo-keto reductase (NADP) activity. Predicted to be involved in vitamin B6 catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YPR127W in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (790083..791120)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene high-affinity Cu transporter CTR1 Neighboring gene Ylh47p Neighboring gene Ant1p Neighboring gene Scd6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The proteome of a wine yeast strain during fermentation, correlation with the transcriptome. Rossignol T, et al. J Appl Microbiol, 2009 Jul. PMID 19245406
    2. Transcriptomic and proteomic approach for understanding the molecular basis of adaptation of Saccharomyces cerevisiae to wine fermentation. Zuzuarregui A, et al. Appl Environ Microbiol, 2006 Jan. PMID 16391125, Free PMC Article
    3. The histone deacetylase Rpd3p is required for transient changes in genomic expression in response to stress. Alejandro-Osorio AL, et al. Genome Biol, 2009. PMID 19470158, Free PMC Article
    4. Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. Lucau-Danila A, et al. J Biol Chem, 2003 Dec 26. PMID 14512416
    5. Regulation of lipid droplet dynamics in Saccharomyces cerevisiae depends on the Rab7-like Ypt7p, HOPS complex and V1-ATPase. Bouchez I, et al. Biol Open, 2015 May 6. PMID 25948753, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxine:NADP 4-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in vitamin B6 catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyridoxine 4-dehydrogenase
    NP_015452.1
    • Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      790083..791120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184224.1 → NP_015452.1  TPA: pyridoxine 4-dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4C4, Q06494
      UniProtKB/TrEMBL
      A0A8H4BV45, A6ZX06, C8ZJE9, N1NXS1
      Conserved Domains (1) summary
      cd19077
      Location:8 → 329
      AKR_AKR8A1-2; AKR8A family of aldo-keto reductase (AKR)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06494.1

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