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    DBF20 serine/threonine-protein kinase DBF20 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856227, updated on 1-Aug-2024

    Summary

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    Gene symbol
    DBF20
    Gene description
    serine/threonine-protein kinase DBF20
    Primary source
    FungiDB:YPR111W
    Locus tag
    YPR111W
    See related
    SGD:S000006315; AllianceGenome:SGD:S000006315; VEuPathDB:YPR111W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including division septum assembly; exit from mitosis; and regulation of mRNA catabolic process. Located in cellular bud neck and spindle pole body. Orthologous to human LATS1 (large tumor suppressor kinase 1) and LATS2 (large tumor suppressor kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DBF20 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (747306..749000)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Gld1p Neighboring gene DNA-directed RNA polymerase core subunit RPC40 Neighboring gene RNA-binding ribosome biosynthesis protein MRD1 Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-molecule mRNA decay measurements reveal promoter- regulated mRNA stability in yeast. Trcek T, et al. Cell, 2011 Dec 23. PMID 22196726, Free PMC Article
    2. The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition. Toyn JH, et al. EMBO J, 1994 Mar 1. PMID 8131744, Free PMC Article
    3. The cell-cycle-regulated budding yeast gene DBF2, encoding a putative protein kinase, has a homologue that is not under cell-cycle control. Toyn JH, et al. Gene, 1991 Jul 31. PMID 1916278
    4. Asymmetric spindle pole localization of yeast Cdc15 kinase links mitotic exit and cytokinesis. Menssen R, et al. Curr Biol, 2001 Mar 6. PMID 11267871
    5. Spo12 is a limiting factor that interacts with the cell cycle protein kinases Dbf2 and Dbf20, which are involved in mitotic chromatid disjunction. Toyn JH, et al. Genetics, 1993 Dec. PMID 8307336, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in division septum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exit from mitosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase DBF20
    NP_015436.1
    • Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      747306..749000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184208.1 → NP_015436.1  TPA: serine/threonine-protein kinase DBF20 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015436.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4B0, E9P8X8, P32328, Q06105
      UniProtKB/TrEMBL
      B3LK75, B5VTQ1, N1NXQ2
      Conserved Domains (1) summary
      cd05600
      Location:157 → 539
      STKc_Sid2p_like; Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32328.2

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