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    FIT2 Fit2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854564, updated on 17-May-2024

    Summary

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    Gene symbol
    FIT2
    Gene description
    Fit2p
    Primary source
    FungiDB:YOR382W
    Locus tag
    YOR382W
    See related
    SGD:S000005909; AllianceGenome:SGD:S000005909; VEuPathDB:YOR382W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in siderophore transport. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FIT2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1059531..1059992)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ferric-chelate reductase Neighboring gene uncharacterized protein Neighboring gene Fit3p Neighboring gene putative ferric-chelate reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Three cell wall mannoproteins facilitate the uptake of iron in Saccharomyces cerevisiae. Protchenko O, et al. J Biol Chem, 2001 Dec 28. PMID 11673473
    2. The Snf1 protein kinase controls the induction of genes of the iron uptake pathway at the diauxic shift in Saccharomyces cerevisiae. Haurie V, et al. J Biol Chem, 2003 Nov 14. PMID 12960168
    3. Loss of vacuolar H+-ATPase (V-ATPase) activity in yeast generates an iron deprivation signal that is moderated by induction of the peroxiredoxin TSA2. Diab HI, et al. J Biol Chem, 2013 Apr 19. PMID 23457300, Free PMC Article
    4. Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae. Lee A, et al. Mol Cell, 2005 Jul 1. PMID 15989963
    5. Multiple reporter gene assays for the assessment and estimation of chemical toxicity. Takahashi J, et al. Environ Sci, 2004. PMID 15746902

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in siderophore transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type cell wall IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fit2p
    NP_015027.1
    • Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1059531..1059992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183802.1 → NP_015027.1  TPA: Fit2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015027.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W375, Q08906
      UniProtKB/TrEMBL
      A0A8H4BW68, A6ZPL0, B3LK36, C7GVG4, C8ZHD0, G2WNP2, N1NWA6
      Conserved Domains (1) summary
      pfam17357
      Location:25 → 110
      FIT1_2; Facilitor Of Iron Transport 1 and 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08906.1

    Gene LinkOut

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