Slc28a1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc28a1provided by MGI
Official Full Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1provided by MGI
Primary source: MGI:MGI:3605073
See related: Ensembl:ENSMUSG00000025726 AllianceGenome:MGI:3605073
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cnt1; CNT 1
Summary: Predicted to enable azole transmembrane transporter activity; pyrimidine- and adenosine-specific:sodium symporter activity; and uridine transmembrane transporter activity. Predicted to be involved in azole transmembrane transport; nucleoside transport; and pyrimidine nucleobase transport. Located in brush border membrane. Is expressed in hemolymphoid system and thymus primordium. Orthologous to human SLC28A1 (solute carrier family 28 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 39.3), small intestine adult (RPKM 22.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 45.71 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (80763017..80820164)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (81113269..81170416)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The concentrative nucleoside transporter-1 (CNT1) promoter was characterized with respect to DNA response elements and their binding factors are reported.
Title: Hepatocyte nuclear factor-4alpha and bile acids regulate human concentrative nucleoside transporter-1 gene expression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)

General gene information

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Markers

44.MMHAP69FRG11.seq (e-PCR)
- UniSTS:124544

D7Dcr34 (e-PCR), detects polymorphism
- UniSTS:507792

34.MMHAP91FLD4.seq (e-PCR)
- UniSTS:124118

D7Mit163 (e-PCR), detects polymorphism
- UniSTS:131058

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables azole transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables azole transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine nucleobase transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables uridine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables uridine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in azole transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in azole transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cytidine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytidine transport	IEA Inferred from Electronic Annotation more info
involved_in cytidine transport	ISO Inferred from Sequence Orthology more info
involved_in nucleoside import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in nucleoside import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleobase transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleobase transport	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleobase transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine-containing compound transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in uridine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uridine transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sodium/nucleoside cotransporter 1

Names: Na(+)/nucleoside cotransporter 1; concentrative nucleoside transporter 1; sodium-coupled nucleoside transporter 1; solute carrier family 28 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.