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    RRP17 Rrp17p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852021, updated on 4-Aug-2024

    Summary

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    Gene symbol
    RRP17
    Gene description
    Rrp17p
    Primary source
    FungiDB:YDR412W
    Locus tag
    YDR412W
    See related
    SGD:S000002820; AllianceGenome:SGD:S000002820; VEuPathDB:YDR412W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 5'-3' exoribonuclease activity and preribosome binding activity. Involved in generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm and nuclear periphery. Is active in nucleolus. Orthologous to human NOL12 (nucleolar protein 12). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RRP17 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1294693..1295400)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein-S-isoprenylcysteine carboxyl O-methyltransferase Neighboring gene Dfm1p Neighboring gene Erd1p Neighboring gene putative aminopeptidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global protein function prediction from protein-protein interaction networks. Vazquez A, et al. Nat Biotechnol, 2003 Jun. PMID 12740586
    2. Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. Snoek IS, et al. FEMS Yeast Res, 2006 May. PMID 16630279
    3. Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness. Tye BW, et al. Elife, 2019 Mar 7. PMID 30843788, Free PMC Article
    4. A panoramic view of yeast noncoding RNA processing. Peng WT, et al. Cell, 2003 Jun 27. PMID 12837249
    5. Puf6 primes 60S pre-ribosome nuclear export at low temperature. Gerhardy S, et al. Nat Commun, 2021 Aug 4. PMID 34349113, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rrp17p is required for efficient exonuclease digestion of the mature 5' ends of 5.8S(S) and 25S rRNAs.
      Title: Rrp17p is a eukaryotic exonuclease required for 5' end processing of Pre-60S ribosomal RNA.
    2. Cell cycle check point proteins (Predicted)
      Title: Global protein function prediction from protein-protein interaction networks.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-3' RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables preribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rrp17p
    NP_010700.3
    • 5' exoribonuclease required for 5' end processing of pre-60S rRNA; binds late pre-60S ribosomes, accompanying them from nucleolus to nuclear periphery; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; yeast null mutant is complemented by expression of human homolog NOL12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1294693..1295400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180720.3 → NP_010700.3  TPA: Rrp17p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010700.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT44, Q04031
      UniProtKB/TrEMBL
      A6ZZ11, B3LFP2, C7GY31, C8Z5X5, G2WBF0, N1P8V2
      Conserved Domains (1) summary
      pfam09805
      Location:18 → 161
      Nop25; Nucleolar protein 12 (25kDa)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04031.1

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