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    NOC2 mRNA-binding ribosome synthesis protein NOC2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854381, updated on 7-Jul-2024

    Summary

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    Gene symbol
    NOC2
    Gene description
    mRNA-binding ribosome synthesis protein NOC2
    Primary source
    FungiDB:YOR206W
    Locus tag
    YOR206W
    See related
    SGD:S000005732; AllianceGenome:SGD:S000005732; VEuPathDB:YOR206W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in ribosomal large subunit biogenesis. Located in nucleoplasm. Part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NOC2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (727512..729644)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DEAD-box ATP-dependent RNA helicase DED1 Neighboring gene Gep3p Neighboring gene DNA-directed RNA polymerase III core subunit RET1 Neighboring gene tyrosine protein phosphatase PTP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coevolution of ribosomal RNA expansion segment 7L and assembly factor Noc2p specializes the ribosome biogenesis pathway between Saccharomyces cerevisiae and Candida albicans. Wang X, et al. Nucleic Acids Res, 2021 May 7. PMID 33823547, Free PMC Article
    2. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Milkereit P, et al. Cell, 2001 May 18. PMID 11371346
    3. Rrp5 establishes a checkpoint for 60S assembly during 40S maturation. Khoshnevis S, et al. RNA, 2019 Sep. PMID 31217256, Free PMC Article
    4. Sen34p depletion blocks tRNA splicing in vivo and delays rRNA processing. Volta V, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16188229
    5. The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats. Dlakić M, et al. RNA, 2004 Mar. PMID 14970380, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coevolution of ribosomal RNA expansion segment 7L and assembly factor Noc2p specializes the ribosome biogenesis pathway between Saccharomyces cerevisiae and Candida albicans.
      Title: Coevolution of ribosomal RNA expansion segment 7L and assembly factor Noc2p specializes the ribosome biogenesis pathway between Saccharomyces cerevisiae and Candida albicans.
    2. The results show that the large ribosomal subunit (LSU) biogenesis factor Noc1p of Saccharomyces cerevisiae can simultaneously interact with the LSU biogenesis factor Noc2p and Rrp5p.
      Title: Rrp5p, Noc1p and Noc2p form a protein module which is part of early large ribosomal subunit precursors in S. cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Noc1p-Noc2p complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Noc1p-Noc2p complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Noc2p-Noc3p complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Noc2p-Noc3p complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mRNA-binding ribosome synthesis protein NOC2
    NP_014849.3
    • Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      727512..729644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183625.3 → NP_014849.3  TPA: mRNA-binding ribosome synthesis protein NOC2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014849.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2R2, P39744, Q08625
      UniProtKB/TrEMBL
      A0A8H4BX61, A6ZP49, B3LJN1, B5VS88, C8ZGW2, N1P3F0
      Conserved Domains (1) summary
      COG5604
      Location:1 → 664
      COG5604; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39744.2

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