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    THI2 Thi2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852542, updated on 18-Sep-2024

    Summary

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    Official Symbol
    THI2
    Official Full Name
    Thi2p
    Primary source
    SGD:S000000444
    Locus tag
    YBR240C
    See related
    AllianceGenome:SGD:S000000444; FungiDB:YBR240C; VEuPathDB:YBR240C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PHO6
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of thiamine biosynthetic process and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See THI2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (700490..701842, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ert1p Neighboring gene Vvs1p Neighboring gene 5'-deoxynucleotidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characteristics of a positive regulatory gene, THI2 (PHO6), of thiamin biosynthesis in Saccharomyces cerevisiae. Nishimura H, et al. FEBS Lett, 1992 Feb 3. PMID 1551422
    2. Partial Decay of Thiamine Signal Transduction Pathway Alters Growth Properties of Candida glabrata. Iosue CL, et al. PLoS One, 2016. PMID 27015653, Free PMC Article
    3. Regulation of thiamine synthesis in Saccharomyces cerevisiae for improved pyruvate production. Xu G, et al. Yeast, 2012 Jun. PMID 22674684
    4. Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae. Nosaka K, et al. Mol Microbiol, 2005 Oct. PMID 16194233
    5. Isolation and characterization of the THI6 gene encoding a bifunctional thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase from Saccharomyces cerevisiae. Nosaka K, et al. J Biol Chem, 1994 Dec 2. PMID 7982968

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of thiamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thi2p
    NP_009799.3
    • Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      700490..701842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178588.3 → NP_009799.3  TPA: Thi2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009799.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQN6, P38141
      UniProtKB/TrEMBL
      A6ZLH9, B3LMS2, B5VEJ0, C7GMT4, D3UEY8, G2W9P3, N1P8J0
      Conserved Domains (1) summary
      pfam00172
      Location:28 → 66
      Zn_clus; Fungal Zn(2)-Cys(6) binuclear cluster domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38141.1

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