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    GPI15 phosphatidylinositol N-acetylglucosaminyltransferase GPI15 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855690, updated on 19-Jun-2024

    Summary

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    Gene symbol
    GPI15
    Gene description
    phosphatidylinositol N-acetylglucosaminyltransferase GPI15
    Primary source
    FungiDB:YNL038W
    Locus tag
    YNL038W
    See related
    SGD:S000004983; AllianceGenome:SGD:S000004983; VEuPathDB:YNL038W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to phosphatidylinositol N-acetylglucosaminyltransferase activity. Involved in GPI anchor biosynthetic process. Predicted to be integral component of membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Orthologous to human PIGH (phosphatidylinositol glycan anchor biosynthesis class H). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GPI15 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    2
    Sequence:
    Chromosome: XIV; NC_001146.8 (557020..557783)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative alanine--tRNA ligase Neighboring gene transcription factor TFIIIB subunit BDP1 Neighboring gene isocitrate dehydrogenase (NAD(+)) IDH1 Neighboring gene carbonate dehydratase NCE103

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ynl038wp (Gpi15p) is the Saccharomyces cerevisiae homologue of human Pig-Hp and participates in the first step in glycosylphosphatidylinositol assembly. Yan BC, et al. Yeast, 2001 Nov. PMID 11746600
    2. Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol. Fu Y, et al. Nat Commun, 2020 Jul 7. PMID 32636417, Free PMC Article
    3. Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum. Kajiwara K, et al. Mol Biol Cell, 2008 May. PMID 18287539, Free PMC Article
    4. Synthetic lethality of cohesins with PARPs and replication fork mediators. McLellan JL, et al. PLoS Genet, 2012. PMID 22412391, Free PMC Article
    5. Genetic Networks Required to Coordinate Chromosome Replication by DNA Polymerases α, δ, and ε in Saccharomyces cerevisiae. Dubarry M, et al. G3 (Bethesda), 2015 Aug 21. PMID 26297725, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol N-acetylglucosaminyltransferase GPI15
    NP_014360.2
    • Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      557020..557783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182877.1 → NP_014360.2  TPA: phosphatidylinositol N-acetylglucosaminyltransferase GPI15 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014360.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1E1, P53961, Q6B1G8
      UniProtKB/TrEMBL
      A6ZS40, B3LNQ0, C7GLW2, C8ZFV4, G2WM65, N1NWP5
      Conserved Domains (1) summary
      pfam10181
      Location:123 → 197
      PIG-H; GPI-GlcNAc transferase complex, PIG-H component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53961.2

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