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    FUN26 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851211, updated on 11-Sep-2024

    Summary

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    Official Symbol
    FUN26
    Primary source
    SGD:S000000020
    Locus tag
    YAL022C
    See related
    AllianceGenome:SGD:S000000020; FungiDB:YAL022C; VEuPathDB:YAL022C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables nicotinamide riboside transmembrane transporter activity and nucleobase transmembrane transporter activity. Involved in nicotinamide riboside transport; nucleobase transport; and transmembrane transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in histiocytosis-lymphadenopathy plus syndrome. Orthologous to several human genes including SLC29A3 (solute carrier family 29 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (108877..110430, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene mitotic regulator LTE1 Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT2 Neighboring gene CCR4-NOT core exoribonuclease subunit CCR4 Neighboring gene Ats1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Characterization of the Saccharomyces cerevisiae Equilibrative Nucleoside Transporter 1 (ScENT1). Boswell-Casteel RC, et al. Molecules, 2018 Mar 22. PMID 29565807, Free PMC Article
    2. FUN26 (function unknown now 26) protein from saccharomyces cerevisiae is a broad selectivity, high affinity, nucleoside and nucleobase transporter. Boswell-Casteel RC, et al. J Biol Chem, 2014 Aug 29. PMID 25035431, Free PMC Article
    3. Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1. Belenky PA, et al. J Biol Chem, 2008 Mar 28. PMID 18258590
    4. A functional link between NAD(+) homeostasis and N-terminal protein acetylation in Saccharomyces cerevisiae. Croft T, et al. J Biol Chem, 2018 Feb 23. PMID 29317496, Free PMC Article
    5. Phosphate-responsive signaling pathway is a novel component of NAD+ metabolism in Saccharomyces cerevisiae. Lu SP, et al. J Biol Chem, 2011 Apr 22. PMID 21349851, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nicotinamide riboside transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinamide riboside transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleobase transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleobase transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleoside transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nicotinamide riboside transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleobase transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleoside transmembrane transporter FUN26
    NP_009380.1
    • High affinity, broad selectivity, nucleoside/nucleobase transporter; vacuolar membrane localized transporter which may regulate the balance of nicotinamide riboside (NmR) levels between the cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis; equilibrative nucleoside transporter (ENT) family member

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      108877..110430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178167.1 → NP_009380.1  TPA: nucleoside transmembrane transporter FUN26 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009380.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPJ6, P31381
      UniProtKB/TrEMBL
      A7A0E6, B3LUV6, B5VDK0, C7GPL3, N1P929
      Conserved Domains (1) summary
      TIGR00939
      Location:81 → 514
      2a57; Equilibrative Nucleoside Transporter (ENT)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31381.1

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