HKR1 Hkr1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: HKR1
Gene description: Hkr1p
Primary source: FungiDB:YDR420W
Locus tag: YDR420W
See related: SGD:S000002828; AllianceGenome:SGD:S000002828; VEuPathDB:YDR420W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables osmosensor activity. Involved in several processes, including (1->3)-beta-D-glucan biosynthetic process; cellular bud site selection; and osmosensory signaling pathway via Sho1 osmosensor. Located in plasma membrane and site of polarized growth. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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interaction between Ste20 and Sho1 contributed to the activation of Hog1 by Hkr1, but not by Msb2.
Title: Yeast osmosensors Hkr1 and Msb2 activate the Hog1 MAPK cascade by different mechanisms.
The osmosensor Hkr1 is required for activation of the yeast cell wall integrity MAPK pathway signaling but Msb2 is not.
Title: Activation of the yeast cell wall integrity MAPK pathway by zymolyase depends on protease and glucanase activities and requires the mucin-like protein Hkr1 but not Msb2.
Data showed that Msb2p had a function in cell polarization through the adaptor protein Sho1p that Hkr1p did not.
Title: The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response.
Hkr1 and Msb2 individually form a complex with Sho1, and, upon high external osmolarity stress, appear to induce Sho1 to generate an intracellular signal
Title: Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables osmosensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables osmosensor activity	IEA Inferred from Electronic Annotation more info
enables osmosensor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in (1->3)-beta-D-glucan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular bud site selection	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular bud site selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyperosmotic response	IBA Inferred from Biological aspect of Ancestor more info
involved_in hyperosmotic response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in osmosensory signaling pathway via Sho1 osmosensor	IBA Inferred from Biological aspect of Ancestor more info
involved_in osmosensory signaling pathway via Sho1 osmosensor	IEA Inferred from Electronic Annotation more info
involved_in osmosensory signaling pathway via Sho1 osmosensor	IGI Inferred from Genetic Interaction more info	PubMed
involved_in osmosensory signaling pathway via Sho1 osmosensor	IPI Inferred from Physical Interaction more info	PubMed
involved_in signal transduction involved in filamentous growth	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in site of polarized growth	IBA Inferred from Biological aspect of Ancestor more info
located_in site of polarized growth	IDA Inferred from Direct Assay more info	PubMed

NP_010708.1

Mucin family member that functions as an osmosensor in the HOG pathway; large, highly glycosylated protein that functions redundantly with Msb2p in Sho1p-mediated osmostresss induction of the HOG signaling pathway; cytoplasmic domain interacts with Ahk1p a scaffold protein that prevents cross talk with the Kss1p MAPK of the filamentous growth pathway; mutant displays defects in beta-1,3 glucan synthesis and bud site selection

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