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    MSB1 Msb1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854360, updated on 1-Aug-2024

    Summary

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    Gene symbol
    MSB1
    Gene description
    Msb1p
    Primary source
    FungiDB:YOR188W
    Locus tag
    YOR188W
    See related
    SGD:S000005714; AllianceGenome:SGD:S000005714; VEuPathDB:YOR188W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in establishment of cell polarity. Located in several cellular components, including cellular bud neck; cellular bud tip; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MSB1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (685767..689180)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene translation elongation factor Tu Neighboring gene Ies4p Neighboring gene glucan 1,3-beta-glucosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pxl1p, a paxillin-like protein in Saccharomyces cerevisiae, may coordinate Cdc42p and Rho1p functions during polarized growth. Gao XD, et al. Mol Biol Cell, 2004 Sep. PMID 15215315, Free PMC Article
    2. Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae. Bender A, et al. Mol Cell Biol, 1991 Mar. PMID 1996092, Free PMC Article
    3. Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1. Bender A, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2690082, Free PMC Article
    4. Msb1 interacts with Cdc42, Boi1, and Boi2 and may coordinate Cdc42 and Rho1 functions during early stage of bud development in budding yeast. Liao Y, et al. PLoS One, 2013. PMID 23785492, Free PMC Article
    5. Mzm1 influences a labile pool of mitochondrial zinc important for respiratory function. Atkinson A, et al. J Biol Chem, 2010 Jun 18. PMID 20404342, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cellular bud tip HDA PubMed 
    located_in cellular bud tip TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Msb1p
    NP_014831.3
    • hypothetical protein; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      685767..689180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183607.3 → NP_014831.3  TPA: Msb1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014831.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2P4, P21339
      UniProtKB/TrEMBL
      N1NWQ9
      Conserved Domains (1) summary
      pfam08101
      Location:68 → 472
      DUF1708; Domain of unknown function (DUF1708)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21339.1

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