U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    BOR1 Bor1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855446, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    BOR1
    Gene description
    Bor1p
    Primary source
    FungiDB:YNL275W
    Locus tag
    YNL275W
    See related
    SGD:S000005219; AllianceGenome:SGD:S000005219; VEuPathDB:YNL275W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables borate efflux transmembrane transporter activity. Involved in borate transport and protein targeting to vacuole. Located in fungal-type vacuole and plasma membrane. Human ortholog(s) of this gene implicated in congenital hemolytic anemia (multiple); corneal dystrophy-perceptive deafness syndrome; corneal endothelial dystrophy (multiple); malaria; and renal tubular acidosis. Orthologous to several human genes including SLC4A1 (solute carrier family 4 member 1 (Diego blood group)); SLC4A10 (solute carrier family 4 member 10); and SLC4A11 (solute carrier family 4 member 11). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See BOR1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (119268..120998)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene homoserine O-acetyltransferase Neighboring gene glyoxylate reductase Neighboring gene Tof1p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Boron-dependent regulation of translation through AUGUAA sequence in yeast. Tsednee M, et al. Yeast, 2020 Dec. PMID 33289202
    2. Protein-Lipid Interactions Stabilize the Oligomeric State of BOR1p from Saccharomyces cerevisiae. Pyle E, et al. Anal Chem, 2019 Oct 15. PMID 31513392
    3. Structure of the SLC4 transporter Bor1p in an inward-facing conformation. Coudray N, et al. Protein Sci, 2017 Jan. PMID 27717063, Free PMC Article
    4. Purification of transmembrane proteins from Saccharomyces cerevisiae for X-ray crystallography. Clark KM, et al. Protein Expr Purif, 2010 Jun. PMID 20045057, Free PMC Article
    5. Transport and regulatory characteristics of the yeast bicarbonate transporter homolog Bor1p. Jennings ML, et al. Am J Physiol Cell Physiol, 2007 Jul. PMID 17459946

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural and functional insights into the mechanism of action of plant borate transporters.
      Title: Structural and functional insights into the mechanism of action of plant borate transporters.
    2. Unlikely that the main function of Bor1 is boron efflux, but may have role in vacuolar dynamics.
      Title: Transport and regulatory characteristics of the yeast bicarbonate transporter homolog Bor1p.
    3. These results suggest that, in addition to the efflux boron transporter BOR1, DUR3 and FPS1 play important roles in regulating the cellular boron concentration.
      Title: Roles of BOR1, DUR3, and FPS1 in boron transport and tolerance in Saccharomyces cerevisiae.
    4. Bor1p is a plasma membrane boron exporter and a key determinant of boron tolerance.
      Title: Saccharomyces cerevisiae Bor1p is a boron exporter and a key determinant of boron tolerance.
    5. enolase stimulates vacuole fusion and enolase and Bor1p regulate selective protein trafficking to the vacuole
      Title: Enolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables borate efflux transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables borate efflux transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables borate efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in borate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in borate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in borate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in borate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in fungal-type vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Bor1p
    NP_014124.1
    • Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      119268..120998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183113.1 → NP_014124.1  TPA: Bor1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014124.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0R9, P53838
      UniProtKB/TrEMBL
      A0A8H4BVG4, A6ZRG9, B3LPB4, B5VQD9, C7GP88, C8ZGP7, G2WLJ1
      Conserved Domains (1) summary
      cl23746
      Location:61 → 475
      Xan_ur_permease; Permease family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53838.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools