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    ERG24 delta(14)-sterol reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855441, updated on 4-Aug-2024

    Summary

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    Gene symbol
    ERG24
    Gene description
    delta(14)-sterol reductase
    Primary source
    FungiDB:YNL280C
    Locus tag
    YNL280C
    See related
    SGD:S000005224; AllianceGenome:SGD:S000005224; VEuPathDB:YNL280C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables delta14-sterol reductase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor) and TM7SF2 (transmembrane 7 superfamily member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ERG24 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (109095..110411, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pop3p Neighboring gene Hch1p Neighboring gene pheromone-regulated protein PRM1 Neighboring gene Caf120p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of ergosterol synthesis by novel antifungal compounds targeting C-14 reductase. Hata M, et al. Med Mycol, 2010 Jun. PMID 20392153
    2. Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site. Jia N, et al. Antimicrob Agents Chemother, 2002 Apr. PMID 11897574, Free PMC Article
    3. Radio-detection high-performance liquid chromatographic enzyme assay for inhibitors of fungal sterol delta 14-reductase. Steel CC. J Chromatogr, 1991 May 31. PMID 1939455
    4. Cloning, sequencing, and disruption of the gene encoding sterol C-14 reductase in Saccharomyces cerevisiae. Lorenz RT, et al. DNA Cell Biol, 1992 Nov. PMID 1418625
    5. Construction and growth properties of a yeast strain defective in sterol 14-reductase. Marcireau C, et al. Curr Genet, 1992 Oct. PMID 1394506

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables delta14-sterol reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables delta14-sterol reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables delta14-sterol reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delta14-sterol reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    delta(14)-sterol reductase
    NP_014119.1
    • C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      109095..110411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183118.1 → NP_014119.1  TPA: delta(14)-sterol reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014119.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0R4, P32462
      UniProtKB/TrEMBL
      A6ZRG5, B3LPB9, B5VQD5, C7GP84, C8ZGP1, G2WLI6, N1NXX5
      Conserved Domains (1) summary
      pfam01222
      Location:8 → 438
      ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32462.1

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