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    RIO2 protein kinase RIO2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855514, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RIO2
    Gene description
    protein kinase RIO2
    Primary source
    FungiDB:YNL207W
    Locus tag
    YNL207W
    See related
    SGD:S000005151; AllianceGenome:SGD:S000005151; VEuPathDB:YNL207W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein kinase activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and positive regulation of RNA import into nucleus. Located in cytosol and nucleus. Orthologous to human RIOK2 (RIO kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RIO2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (255353..256630)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Hsp70 family ATPase SSB2 Neighboring gene uncharacterized protein Neighboring gene Rtt106p Neighboring gene Sps18p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Release of the ribosome biogenesis factor Bud23 from small subunit precursors in yeast. Black JJ, et al. RNA, 2022 Mar. PMID 34934010, Free PMC Article
    2. Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes. Ferreira-Cerca S, et al. Nucleic Acids Res, 2014 Jul. PMID 24948609, Free PMC Article
    3. Ribosomal protein uS7/Rps5 serine-223 in protein kinase-mediated phosphorylation and ribosomal small subunit maturation. Tomioka M, et al. Sci Rep, 2018 Jan 19. PMID 29352143, Free PMC Article
    4. The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation. Rössler I, et al. RNA Biol, 2022. PMID 35438042, Free PMC Article
    5. Cracking pre-40S ribosomal subunit structure by systematic analyses of RNA-protein cross-linking. Granneman S, et al. EMBO J, 2010 Jun 16. PMID 20453830, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Release of the ribosome biogenesis factor Bud23 from small subunit precursors in yeast.
      Title: Release of the ribosome biogenesis factor Bud23 from small subunit precursors in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of RNA import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase RIO2
    NP_014192.1
    • Essential serine kinase involved in the processing of 20S pre-rRNA; involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      255353..256630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183045.1 → NP_014192.1  TPA: protein kinase RIO2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014192.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Y3, P40160
      UniProtKB/TrEMBL
      A0A6A5Q8T7, A6ZRN3, B3LP51, B5VQK4, C7GTH5, C8ZG25, G2WLQ6, N1P447
      Conserved Domains (2) summary
      COG0478
      Location:1 → 339
      RIO2; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]
      pfam04931
      Location:355 → 407
      DNA_pol_phi; DNA polymerase phi
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40160.1

    Gene LinkOut

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