U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NOP4 mRNA-binding ribosome biosynthesis protein NOP4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856063, updated on 29-Jun-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    NOP4
    Gene description
    mRNA-binding ribosome biosynthesis protein NOP4
    Primary source
    FungiDB:YPL043W
    Locus tag
    YPL043W
    See related
    SGD:S000005964; AllianceGenome:SGD:S000005964; VEuPathDB:YPL043W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NOP77
    Summary
    Enables large ribosomal subunit rRNA binding activity. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Human ortholog(s) of this gene implicated in alopecia, neurologic defects, and endocrinopathy syndrome. Orthologous to human RBM28 (RNA binding motif protein 28). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NOP4 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (469939..471996)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene elongin C Neighboring gene tethering complex subunit VPS16 Neighboring gene cyclin-dependent serine/threonine protein kinase SSN3 Neighboring gene Mrx11p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The yeast nucleolar protein Nop4p contains four RNA recognition motifs necessary for ribosome biogenesis. Sun C, et al. J Biol Chem, 1997 Oct 3. PMID 9312154
    2. The yeast NOP4 gene product is an essential nucleolar protein required for pre-rRNA processing and accumulation of 60S ribosomal subunits. Sun C, et al. EMBO J, 1994 Jul 1. PMID 8039505, Free PMC Article
    3. Synthetic lethality with fibrillarin identifies NOP77p, a nucleolar protein required for pre-rRNA processing and modification. Bergès T, et al. EMBO J, 1994 Jul 1. PMID 8039506, Free PMC Article
    4. Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae. Qiu H, et al. Mol Cell Biol, 2008 Jun. PMID 18378690, Free PMC Article
    5. Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. Gautier T, et al. Mol Cell Biol, 1997 Dec. PMID 9372940, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mRNA-binding ribosome biosynthesis protein NOP4
    NP_015282.1
    • Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs); human ortholog RBM28 implicated in ANE syndrome

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      469939..471996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183857.1 → NP_015282.1  TPA: mRNA-binding ribosome biosynthesis protein NOP4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015282.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3X0, P37838
      UniProtKB/TrEMBL
      A0A8H4BTX6, A6ZWK4, C7GU10, N1NW50
      Conserved Domains (4) summary
      cd12674
      Location:26 → 104
      RRM1_Nop4p; RNA recognition motif 1 (RRM1) found in yeast nucleolar protein 4 (Nop4p) and similar proteins
      cd12675
      Location:147 → 229
      RRM2_Nop4p; RNA recognition motif 2 (RRM2) found in yeast nucleolar protein 4 (Nop4p) and similar proteins
      cd12676
      Location:289 → 387
      RRM3_Nop4p; RNA recognition motif 3 (RRM3) found in yeast nucleolar protein 4 (Nop4p) and similar proteins
      cd12677
      Location:458 → 620
      RRM4_Nop4p; RNA recognition motif 4 (RRM4) found in yeast nucleolar protein 4 (Nop4p) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37838.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools