Fhl3 four and a half LIM domains 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fhl3provided by MGI
Official Full Name: four and a half LIM domains 3provided by MGI
Primary source: MGI:MGI:1341092
See related: Ensembl:ENSMUSG00000032643 AllianceGenome:MGI:1341092
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SLIM2
Summary: Enables actin binding activity. Acts upstream of or within actin cytoskeleton organization. Located in Z disc; nucleus; and stress fiber. Is expressed in several structures, including genitourinary system; heart; lung; skeletal muscle; and thymus. Orthologous to human FHL3 (four and a half LIM domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 16.6), stomach adult (RPKM 11.5) and 22 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4 D2.2; 4 57.88 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (124589750..124602404)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (124695964..124708611)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Four and a half LIM domain protein 3 could interact with MyoD, cyclic AMP-responsive elements and phosphorylated cAMP response element binding protein in vivo
Title: FHL3 differentially regulates the expression of MyHC isoforms through interactions with MyoD and pCREB.
These studies demonstrate that Sox15, Fhl3 and Foxk1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration.
Title: Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells.
FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells
Title: The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor.
Actin was identified as a FHL3 binding partner; FHL3 is a significant regulator of actin cytoskeletal dynamics in skeletal myoblasts.
Title: FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: four and a half LIM domains protein 3

Names: skeletal muscle LIM-protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418979.1 → NP_001405908.1 four and a half LIM domains protein 3

Status: VALIDATED

Source sequence(s)

AL606907

UniProtKB/Swiss-Prot

A6H6N4, Q9JLP5, Q9R059, Q9WUH3

UniProtKB/TrEMBL

F2Z455
NM_001418980.1 → NP_001405909.1 four and a half LIM domains protein 3

Status: VALIDATED

Source sequence(s)

AL606907

UniProtKB/Swiss-Prot

A6H6N4, Q9JLP5, Q9R059, Q9WUH3

UniProtKB/TrEMBL

F2Z455
NM_001418981.1 → NP_001405910.1 four and a half LIM domains protein 3

Status: VALIDATED

Source sequence(s)

AL606907

UniProtKB/Swiss-Prot

A6H6N4, Q9JLP5, Q9R059, Q9WUH3

UniProtKB/TrEMBL

F2Z455
NM_001418982.1 → NP_001405911.1 four and a half LIM domains protein 3

Status: VALIDATED

Source sequence(s)

AL606907

UniProtKB/Swiss-Prot

A6H6N4, Q9JLP5, Q9R059, Q9WUH3

UniProtKB/TrEMBL

F2Z455
NM_010213.4 → NP_034343.2 four and a half LIM domains protein 3

See identical proteins and their annotated locations for NP_034343.2

Status: VALIDATED

Source sequence(s)

AL606907

Consensus CDS

CCDS38874.1

UniProtKB/Swiss-Prot

A6H6N4, Q9JLP5, Q9R059, Q9WUH3

UniProtKB/TrEMBL

F2Z455

Related

ENSMUSP00000040150.6, ENSMUST00000038684.6

Conserved Domains (4) summary

cd09346
Location:162 → 213

LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)

cd09423
Location:36 → 94

LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)

cd09427
Location:98 → 155

LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)

cl02475
Location:221 → 285

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RNA

NR_184996.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL606907
NR_184997.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL606907
NR_184998.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL606907

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

124589750..124602404

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163678.1 → XP_036019571.1 four and a half LIM domains protein 3 isoform X2

UniProtKB/TrEMBL

F2Z455

Conserved Domains (4) summary

cd09346
Location:170 → 221

LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)

cd09423
Location:44 → 102

LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)

cd09427
Location:106 → 163

LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)

cl02475
Location:229 → 293

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers