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    sulf2a sulfatase 2a [ Danio rerio (zebrafish) ]

    Gene ID: 393910, updated on 27-Mar-2024

    Summary

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    Official Symbol
    sulf2aprovided by ZNC
    Official Full Name
    sulfatase 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-759
    See related
    Ensembl:ENSDARG00000018423 AllianceGenome:ZFIN:ZDB-GENE-040426-759
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Sulf1; sulf2; zgc:55612
    Summary
    Predicted to enable N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Acts upstream of or within with a positive effect on epithelial structure maintenance. Predicted to be located in Golgi stack and extracellular space. Predicted to be active in cell surface; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including central nervous system; head; hypochord; neural plate; and neural tube. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See sulf2a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (24907469..24993225)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (24669853..24755609)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene leiomodin 1b (smooth muscle) Neighboring gene translocase of inner mitochondrial membrane 17 homolog A (yeast) Neighboring gene Rho GTPase activating protein 46a Neighboring gene PHD finger protein 20, a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2. Gorsi B, et al. Dev Dyn, 2010 Dec. PMID 20981828
    2. Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord. Danesin C, et al. Sci Rep, 2021 Jan 8. PMID 33420239, Free PMC Article
    3. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish. Schenk H, et al. Biomed Res Int, 2019. PMID 31428635, Free PMC Article
    4. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord.
      Title: Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord.
    2. Sulf2 expression is almost entirely restricted to the CNS.
      Title: Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55612

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arylsulfatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfuric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chondrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_positive_effect epithelial structure maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in esophagus smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glial cell-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glomerular basement membrane development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innervation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within_positive_effect oligodendrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within_negative_effect ventral spinal cord interneuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    extracellular sulfatase Sulf-2a; sulfatase 2a
    Names
    sulfatase 2
    NP_957230.1
    XP_005169326.1
    XP_005169327.1
    XP_021335240.1
    XP_021335241.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200936.1 → NP_957230.1  extracellular sulfatase Sulf-2a precursor

      See identical proteins and their annotated locations for NP_957230.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045403
      UniProtKB/TrEMBL
      Q7ZVU8
      Related
      ENSDARP00000009647.9, ENSDART00000008038.11
      Conserved Domains (3) summary
      pfam12548
      Location:541 → 670
      DUF3740; Sulfatase protein
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:757 → 806
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      24907469..24993225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479566.1 → XP_021335241.1  sulfatase 2a isoform X3

      UniProtKB/TrEMBL
      A0A8M9QHJ3
      Conserved Domains (2) summary
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:539 → 671
      DUF3740; Sulfatase protein

    2. XM_005169269.4 → XP_005169326.1  sulfatase 2a isoform X1

      See identical proteins and their annotated locations for XP_005169326.1

      UniProtKB/TrEMBL
      A0A8M2BGI3
      Conserved Domains (3) summary
      pfam12548
      Location:541 → 670
      DUF3740; Sulfatase protein
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:758 → 807
      ALP_like; alkaline phosphatases and sulfatases

    3. XM_021479565.1 → XP_021335240.1  sulfatase 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M9QLI6
      Conserved Domains (3) summary
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:539 → 671
      DUF3740; Sulfatase protein
      cl23718
      Location:757 → 806
      ALP_like; alkaline phosphatases and sulfatases

    4. XM_005169270.4 → XP_005169327.1  sulfatase 2a isoform X1

      See identical proteins and their annotated locations for XP_005169327.1

      UniProtKB/TrEMBL
      A0A8M2BGI3
      Conserved Domains (3) summary
      pfam12548
      Location:541 → 670
      DUF3740; Sulfatase protein
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:758 → 807
      ALP_like; alkaline phosphatases and sulfatases

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394821.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      88784..178943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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