cnot7 CCR4-NOT transcription complex, subunit 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cnot7provided by ZNC
Official Full Name: CCR4-NOT transcription complex, subunit 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-061013-29
See related: Ensembl:ENSDARG00000032116 AllianceGenome:ZFIN:ZDB-GENE-061013-29
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CAF1; fd59c07; fj07d05; wu:fd59c07; wu:fj07d05; zgc:153168
Summary: Predicted to enable poly(A)-specific ribonuclease activity. Acts upstream of or within mRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (30413644..30424856)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (30073444..30084542)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show pervasive yet nonuniform contributions of the decapping enzyme Dcp2 and the deadenylase Cnot7 to maternal mRNA clearance.
Title: Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal mRNA clearance in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fj07d05.x1 (e-PCR)
- UniSTS:198447

fd59c07.x1 (e-PCR)
- UniSTS:195751

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(A)-specific ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A)-specific ribonuclease activity	IEA Inferred from Electronic Annotation more info
enables poly(A)-specific ribonuclease activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mRNA catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA-mediated gene silencing by mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated gene silencing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	IEA Inferred from Electronic Annotation more info
part_of CCR4-NOT complex	ISS Inferred from Sequence or Structural Similarity more info
part_of CCR4-NOT core complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CCR4-NOT transcription complex subunit 7

Names: CAF-1; CCR4-associated factor 1

NP_001070723.1

EC 3.1.13.4

XP_021336741.1

EC 3.1.13.4

XP_021336742.1

EC 3.1.13.4

XP_021336743.1

EC 3.1.13.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077255.1 → NP_001070723.1 CCR4-NOT transcription complex subunit 7

See identical proteins and their annotated locations for NP_001070723.1

Status: PROVISIONAL

Source sequence(s)

BC124650

UniProtKB/Swiss-Prot

Q08BM8

Related

ENSDARP00000087385.5, ENSDART00000092953.7

Conserved Domains (1) summary

cl23804
Location:1 → 279

CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

30413644..30424856

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021481066.1 → XP_021336741.1 CCR4-NOT transcription complex subunit 7 isoform X1

UniProtKB/TrEMBL

A0A8M9QKP5

Conserved Domains (1) summary

cl23804
Location:1 → 288

CAF1; CAF1 family ribonuclease
XM_021481067.1 → XP_021336742.1 CCR4-NOT transcription complex subunit 7 isoform X1

UniProtKB/TrEMBL

A0A8M9QKP5

Conserved Domains (1) summary

cl23804
Location:1 → 288

CAF1; CAF1 family ribonuclease
XM_021481068.1 → XP_021336743.1 CCR4-NOT transcription complex subunit 7 isoform X2

UniProtKB/TrEMBL

A0A8M9QB61

Conserved Domains (1) summary

cl23804
Location:1 → 182

CAF1; CAF1 family ribonuclease