cahz carbonic anhydrase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cahzprovided by ZNC
Official Full Name: carbonic anhydraseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-39
See related: Ensembl:ENSDARG00000011166 AllianceGenome:ZFIN:ZDB-GENE-980526-39
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cah; CAH-Z; cb588; id:ibd5016; wu:fj65c09; wu:cegs2190
Summary: Enables carbonate dehydratase activity. Acts upstream of or within carbon dioxide transport and hypotonic salinity response. Predicted to be active in cytoplasm. Is expressed in several structures, including hematopoietic system; mesoderm; nervous system; pleuroperitoneal region; and presumptive blood. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to several human genes including CA2 (carbonic anhydrase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (29477383..29485105, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (29493850..29501572, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj65c09.x1 (e-PCR)
- UniSTS:199756

CAH-Z (e-PCR)
- UniSTS:204684

CAH (e-PCR)
- UniSTS:205309

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables carbonate dehydratase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables carbonate dehydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbon dioxide transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within carbon dioxide transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within carbon dioxide transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypotonic salinity response	IDA Inferred from Direct Assay more info	PubMed
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of pH	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: carbonic anhydrase

Names: ca2b; carbonate dehydratase; zCA2-like b; zCAb

NP_571185.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131110.1 → NP_571185.1 carbonic anhydrase

See identical proteins and their annotated locations for NP_571185.1

Status: PROVISIONAL

Source sequence(s)

U55177

UniProtKB/Swiss-Prot

Q92051

Related

ENSDARP00000022592.5, ENSDART00000013411.6

Conserved Domains (1) summary

cd03119
Location:1 → 259

alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...