srsf2b serine and arginine rich splicing factor 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: srsf2bprovided by ZNC
Official Full Name: serine and arginine rich splicing factor 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2420
See related: Ensembl:ENSDARG00000103893 AllianceGenome:ZFIN:ZDB-GENE-030131-2420
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55876; zgc:77420; wu:fc07d01
Summary: Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in acute myeloid leukemia; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to human SRSF2 (serine and arginine rich splicing factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (60594130..60602432, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (60514329..60522628, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/arginine-rich splicing factor 2b

Names: splicing factor, arginine/serine-rich 2 (SC-35)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199651.2 → NP_955945.2 serine/arginine-rich splicing factor 2b

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.

Source sequence(s)

BC065971, CU463857

UniProtKB/TrEMBL

A0A8M1PD80, Q6NZT9

Related

ENSDARP00000131299.1, ENSDART00000163235.2

Conserved Domains (2) summary

COG0724
Location:5 → 91

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12311
Location:16 → 88

RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

RNA

NR_132430.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses alternate splice sites in the 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC065971, CU463857, EH606115