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    hibadha 3-hydroxyisobutyrate dehydrogenase a [ Danio rerio (zebrafish) ]

    Gene ID: 445252, updated on 27-Mar-2024

    Summary

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    Official Symbol
    hibadhaprovided by ZNC
    Official Full Name
    3-hydroxyisobutyrate dehydrogenase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-264
    See related
    Ensembl:ENSDARG00000102906 AllianceGenome:ZFIN:ZDB-GENE-040801-264
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb07f02; zgc:100804
    Summary
    Predicted to enable 3-hydroxyisobutyrate dehydrogenase activity. Predicted to be involved in valine catabolic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Predicted to be active in mitochondrion. Is expressed in mesenchyme pectoral fin and myoblast. Orthologous to human HIBADH (3-hydroxyisobutyrate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See hibadha in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (19600268..19657539)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (20027324..20084588)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 5a Neighboring gene JAZF zinc finger 1a Neighboring gene Tax1 (human T-cell leukemia virus type I) binding protein 1a Neighboring gene homeobox A13a Neighboring gene even-skipped homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tri-phasic expression of posterior Hox genes during development of pectoral fins in zebrafish: implications for the evolution of vertebrate paired appendages. Ahn D, et al. Dev Biol, 2008 Oct 1. PMID 18638469
    2. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3-hydroxyisobutyrate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyisobutyrate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within branched-chain amino acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in valine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in valine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxyisobutyrate dehydrogenase a
    NP_001003646.1
    XP_009292434.1
    XP_021323726.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003646.2 → NP_001003646.1  3-hydroxyisobutyrate dehydrogenase a

      See identical proteins and their annotated locations for NP_001003646.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078207
      UniProtKB/TrEMBL
      Q6DC72
      Related
      ENSDARP00000130898.1, ENSDART00000160134.2
      Conserved Domains (3) summary
      TIGR01692
      Location:37 → 324
      HIBADH; 3-hydroxyisobutyrate dehydrogenase
      pfam03446
      Location:32 → 193
      NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
      pfam14833
      Location:196 → 323
      NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      19600268..19657539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294159.3 → XP_009292434.1  3-hydroxyisobutyrate dehydrogenase a isoform X2

      UniProtKB/TrEMBL
      A0A8M3AKW8
      Conserved Domains (2) summary
      pfam03446
      Location:32 → 193
      NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
      pfam14833
      Location:196 → 226
      NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

    2. XM_021468051.1 → XP_021323726.1  3-hydroxyisobutyrate dehydrogenase a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PN96
      Conserved Domains (1) summary
      cl25951
      Location:37 → 224
      NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
    Nucleotide Protein Strain
    Heading Accession and Version

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