REI1 Rei1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: REI1
Gene description: Rei1p
Primary source: FungiDB:YBR267W
Locus tag: YBR267W
See related: SGD:S000000471; AllianceGenome:SGD:S000000471; VEuPathDB:YBR267W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables sequence-specific DNA binding activity. Involved in several processes, including budding cell bud growth; nucleocytoplasmic transport; and ribosomal large subunit biogenesis. Located in cytoplasm. Part of preribosome, large subunit precursor. Orthologous to human ZNF622 (zinc finger protein 622). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See REI1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (739841..741022)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study reports the cryo-electron microscopy (cryo-EM) structure of the yeast 60S subunit in complex with the biogenesis factors Rei1, Arx1, and Alb1 at 3.4 A resolution; provides genetic and biochemical evidence that failure to insert the C terminus of Rei1 precludes subsequent steps of 60S maturation.
Title: Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation.
biochemically characterized ribosomal complexes of the yeast 60S-biogenesis factor Arx1 and late-maturation factors Rei1 and Jjj1 and determined their cryo-EM structures
Title: Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit.
both Rei1 and Jjj1 are required for dissociation of Arx1 from the pre-60 S subunit, and the region of Jjj1 that mediates interaction with Rei1 is required in vivo for 60 S subunit biogenesis
Title: The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1.
strains lacking both Reh1 and Rei1 accumulate salt-labile 60S subunits, suggesting that Reh1/Rei1 is necessary for the cytoplasmic 60S subunit to adopt its mature, stable form
Title: Functional redundancy of yeast proteins Reh1 and Rei1 in cytoplasmic 60S subunit maturation.
Preferentially involved in the recycling of ribosomal pre-60S factors Arx1 and Alb1.
Title: The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling of preribosomal factors in Saccharomyces cerevisiae.
The REI1 is a new member of genes belonging to the mitotic signaling network that negatively regulates Swe1 kinase.
Title: Ybr267w is a new cytoplasmic protein belonging to the mitotic signaling network of Saccharomyces cerevisiae.
A model is presented in which Rei1 is a key factor for the coordinated dissociation and recycling of the last pre-60S factors before newly synthesized large ribosomal subunits enter translation.
Title: A functional network involved in the recycling of nucleocytoplasmic pre-60S factors.
Nuclear recycling of the pre-60S ribosomal subunit associated factor Arx1 depends on Rei1.
Title: Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	HDA more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in budding cell bud growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleocytoplasmic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosomal large subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info
part_of preribosome, large subunit precursor	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Rei1p

NP_009825.4

Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

739841..741022

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178615.4 → NP_009825.4 TPA: Rei1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009825.4

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQR3, P38344

UniProtKB/TrEMBL

A0A8H4BTF6, B3LMP5, C7GMW4, D3UF14, N1P9N0

Conserved Domains (3) summary

PTZ00448
Location:9 → 50

PTZ00448; hypothetical protein; Provisional

sd00020
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12756
Location:164 → 263

zf-C2H2_2; C2H2 type zinc-finger (2 copies)