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    LYS20 homocitrate synthase LYS20 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851346, updated on 29-Jun-2024

    Summary

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    Gene symbol
    LYS20
    Gene description
    homocitrate synthase LYS20
    Primary source
    FungiDB:YDL182W
    Locus tag
    YDL182W
    See related
    SGD:S000002341; AllianceGenome:SGD:S000002341; VEuPathDB:YDL182W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables homocitrate synthase activity. Involved in DNA repair; histone displacement; and lysine biosynthetic process via aminoadipic acid. Located in nucleus. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to several human genes including HMGCLL1 (3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LYS20 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (133437..134723)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L41A Neighboring gene Mrx19p Neighboring gene ATPase inhibitor Neighboring gene Ait1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-Level Production of Lysine in the Yeast Saccharomyces cerevisiae by Rational Design of Homocitrate Synthase. Isogai S, et al. Appl Environ Microbiol, 2021 Jul 13. PMID 33990312, Free PMC Article
    2. The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae. Quezada H, et al. Mol Microbiol, 2011 Nov. PMID 21895798
    3. Acid-base chemical mechanism of homocitrate synthase from Saccharomyces cerevisiae. Qian J, et al. Biochemistry, 2006 Oct 3. PMID 17002313
    4. Stabilization and characterization of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. Andi B, et al. Arch Biochem Biophys, 2004 Jan 15. PMID 14984204
    5. Lysine-overproducing mutants of Saccharomyces cerevisiae baker's yeast isolated in continuous culture. Gasent-Ramírez JM, et al. Appl Environ Microbiol, 1997 Dec. PMID 9406398, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lys20 appears to have evolved as a bifunctional protein that connects cellular metabolism with chromatin functions
      Title: Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables homocitrate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables homocitrate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables homocitrate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables homocitrate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lysine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process via aminoadipic acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysine biosynthetic process via aminoadipic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process via aminoadipic acid IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oxoacid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small molecule biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homocitrate synthase LYS20
    NP_010099.1
    • Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      133437..134723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180242.1 → NP_010099.1  TPA: homocitrate synthase LYS20 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010099.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRH0, P48570
      UniProtKB/TrEMBL
      A0A8H8UMB6, A6ZXE9, B3LH66, B5VF91, C8Z6C2, G2WBY3, N1PAJ0
      Conserved Domains (1) summary
      cd07948
      Location:23 → 284
      DRE_TIM_HCS; Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48570.1

    Gene LinkOut

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