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    PSF1 DNA replication protein PSF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851576, updated on 1-Aug-2024

    Summary

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    Gene symbol
    PSF1
    Gene description
    DNA replication protein PSF1
    Primary source
    FungiDB:YDR013W
    Locus tag
    YDR013W
    See related
    SGD:S000002420; AllianceGenome:SGD:S000002420; VEuPathDB:YDR013W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CDC101
    Summary
    Involved in DNA-dependent DNA replication and double-strand break repair via break-induced replication. Part of CMG complex; GINS complex; and replication fork protection complex. Human ortholog(s) of this gene implicated in immunodeficiency 55. Orthologous to human GINS1 (GINS complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PSF1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (473157..473783)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette transporter SNQ2 Neighboring gene ribosomal 60S subunit protein L4B Neighboring gene Rad61p Neighboring gene Hed1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CysB motif of Rev3p involved in the formation of the four-subunit DNA polymerase ζ is required for defective-replisome-induced mutagenesis. Szwajczak E, et al. Mol Microbiol, 2017 Nov. PMID 28941243
    2. Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Kanemaki M, et al. Nature, 2003 Jun 12. PMID 12768207
    3. Disruption and functional analysis of six ORFs on chromosome IV: YDR013w, YDR014w, YDR015c, YDR018c, YDR020c, YDR021w (FAL1). Dardalhon M, et al. Yeast, 2000 Feb. PMID 10649455
    4. A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome. Simon AC, et al. Nature, 2014 Jun 12. PMID 24805245, Free PMC Article
    5. Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design. Wu Y, et al. Angew Chem Int Ed Engl, 2017 Oct 9. PMID 28815832

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recombination and Pol zeta Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol epsilon Interaction.
      Title: Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ε Interaction.
    2. The association of Dpb2 with the B domain of Psf1 is required for initiation, and afterwards it links the leading strand DNA polymerase to the Cdc45-MCM-GINS helicase within the replisome.
      Title: Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome.
    3. GINS (Psf1, Psf2, Psf3, and Sld5) and Sld3 compete with one another for Mcm2-7 and Cdc45 binding
      Title: GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA strand elongation involved in mitotic DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via break-induced replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DNA replication preinitiation complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of DNA replication preinitiation complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of GINS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of replication fork protection complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication protein PSF1
    NP_010296.3
    • Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      473157..473783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180321.3 → NP_010296.3  TPA: DNA replication protein PSF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010296.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRZ9, Q12488
      UniProtKB/TrEMBL
      A6ZXX8, B3LGP8, B5VFS1, C7GLY3, C8Z4T2, G2WAC0, N1P7Y6
      Conserved Domains (1) summary
      COG5230
      Location:1 → 208
      COG5230; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12488.1

    Gene LinkOut

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