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    NSE3 Smc5-Smc6 complex subunit NSE3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851882, updated on 29-Jun-2024

    Summary

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    Gene symbol
    NSE3
    Gene description
    Smc5-Smc6 complex subunit NSE3
    Primary source
    FungiDB:YDR288W
    Locus tag
    YDR288W
    See related
    SGD:S000002696; AllianceGenome:SGD:S000002696; VEuPathDB:YDR288W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to SUMO transferase activity. Involved in DNA repair. Located in cytoplasm and nucleus. Part of Smc5-Smc6 complex. Human ortholog(s) of this gene implicated in Prader-Willi syndrome. Orthologous to several human genes including MAGEA1 (MAGE family member A1); MAGEA10 (MAGE family member A10); and MAGEA11 (MAGE family member A11). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NSE3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1037195..1038106)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mgp12p Neighboring gene inositol monophosphate 1-phosphatase INM2 Neighboring gene Rtt103p Neighboring gene ATP-dependent 3'-5' DNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE. Moradi-Fard S, et al. PLoS Genet, 2016 Aug. PMID 27564449, Free PMC Article
    2. Interaction of the Saccharomyces cerevisiae RING-domain protein Nse1 with Nse3 and the Smc5/6 complex is required for chromosome replication and stability. Wani S, et al. Curr Genet, 2018 Jun. PMID 29119272
    3. Smc5/6 in the rDNA modulates lifespan independently of Fob1​. Moradi-Fard S, et al. Aging Cell, 2021 Jun. PMID 33979898, Free PMC Article
    4. Genetic evidence for functional interaction of Smc5/6 complex and Top1 with spatial frequency of replication origins required for maintenance of chromosome stability. Rai R, et al. Curr Genet, 2017 Aug. PMID 28204881
    5. Nse1 and Nse4, subunits of the Smc5-Smc6 complex, are involved in Dictyostelium development upon starvation. Taniura H, et al. Dev Growth Differ, 2015 Aug. PMID 26036668

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. nse3-1/ sir4 Delta double mutants show additive defects for telomere shortening and TPE indicating the contribution of Smc5/6 to telomere homeostasis is only in partial overlap with SIR factor silencing. These findings support a role for Smc5/6 in telomere maintenance that is separate from its canonical role(s) in HR-mediated events during replication and telomere elongation.
      Title: Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.
    2. Smc5 and Smc6 associate with each other at their hinge regions and constitute the backbone of the complex, whereas the Nse1-6 subunits form three distinct subcomplexes/entities that interact with different regions of Smc5 and Smc6.
      Title: Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to SUMO transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Smc5-Smc6 complex subunit NSE3
    NP_010574.1
    • Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1037195..1038106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180596.1 → NP_010574.1  TPA: Smc5-Smc6 complex subunit NSE3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010574.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSR8, Q05541
      UniProtKB/TrEMBL
      A0A8H8UNJ0, A6ZYN7, B3LG06, B5VGG4, N1P6T2
      Conserved Domains (1) summary
      pfam01454
      Location:31 → 269
      MAGE; MAGE family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05541.1

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