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    PEP7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851923, updated on 11-Sep-2024

    Summary

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    Official Symbol
    PEP7
    Primary source
    SGD:S000002731
    Locus tag
    YDR323C
    See related
    AllianceGenome:SGD:S000002731; FungiDB:YDR323C; VEuPathDB:YDR323C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VAC1; VPL21; VPS19; VPT19
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity. Involved in several processes, including post-Golgi vesicle-mediated transport; vacuole inheritance; and vesicle docking involved in exocytosis. Located in cytoplasmic side of endosome membrane. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1112480..1114027, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL35 Neighboring gene F1F0 ATP synthase subunit e Neighboring gene Utp4p Neighboring gene condensin subunit YCG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pep7p provides a novel protein that functions in vesicle-mediated transport between the yeast Golgi and endosome. Webb GC, et al. Mol Biol Cell, 1997 May. PMID 9168472, Free PMC Article
    2. Molecular characterization of VAC1, a gene required for vacuole inheritance and vacuole protein sorting. Weisman LS, et al. J Biol Chem, 1992 Jan 5. PMID 1730622
    3. Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation. Weisman LS, et al. Proc Natl Acad Sci U S A, 1990 Feb. PMID 1689059, Free PMC Article
    4. In vitro reactions of vacuole inheritance in Saccharomyces cerevisiae. Conradt B, et al. J Cell Biol, 1992 Dec. PMID 1334958, Free PMC Article
    5. Proteinase mutants of Saccharomyces cerevisiae. Jones EW. Genetics, 1977 Jan. PMID 320092, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi to vacuole transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in vacuole inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle docking involved in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol-3-phosphate binding protein
    NP_010610.3
    • Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1112480..1114027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180631.3 → NP_010610.3  TPA: phosphatidylinositol-3-phosphate binding protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010610.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSV6, P32609, Q99229
      UniProtKB/TrEMBL
      A6ZYS6, G2WB63, N1P6X4
      Conserved Domains (3) summary
      cd15737
      Location:211 → 293
      FYVE2_Vac1p_like; FYVE domain 2 found in yeast protein VAC1 (Vac1p) and similar proteins
      cd15761
      Location:65 → 141
      FYVE1_Vac1p_like; FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins
      pfam11464
      Location:467 → 502
      Rbsn; Rabenosyn Rab binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32609.2

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