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    SDH9 succinate dehydrogenase SDH1b [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853405, updated on 1-Aug-2024

    Summary

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    Gene symbol
    SDH9
    Gene description
    succinate dehydrogenase SDH1b
    Primary source
    FungiDB:YJL045W
    Locus tag
    YJL045W
    See related
    SGD:S000003581; AllianceGenome:SGD:S000003581; VEuPathDB:YJL045W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables succinate dehydrogenase (ubiquinone) activity. Involved in cellular respiration. Located in mitochondrion. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SDH9 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (356024..357928)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene tRNA-Asp Neighboring gene GTPase-activating protein GYP6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of sdh1 mutations by the SDH1b gene of Saccharomyces cerevisiae. Colby G, et al. Yeast, 1998 Aug. PMID 9730279
    2. Effect of gene disruption of succinate dehydrogenase on succinate production in a sake yeast strain. Kubo Y, et al. J Biosci Bioeng, 2000. PMID 16232921
    3. The transcriptional activator Cat8p provides a major contribution to the reprogramming of carbon metabolism during the diauxic shift in Saccharomyces cerevisiae. Haurie V, et al. J Biol Chem, 2001 Jan 5. PMID 11024040
    4. The Crabtree Effect Shapes the Saccharomyces cerevisiae Lag Phase during the Switch between Different Carbon Sources. Perez-Samper G, et al. mBio, 2018 Oct 30. PMID 30377274, Free PMC Article
    5. Evaluation of genes involved in oxidative phosphorylation in yeast by developing a simple and rapid method to measure mitochondrial ATP synthetic activity. Ye X, et al. Microb Cell Fact, 2015 Apr 16. PMID 25880855, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate dehydrogenase (quinone) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables succinate dehydrogenase (quinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables succinate dehydrogenase (quinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular respiration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, succinate to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex II (succinate dehydrogenase) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    succinate dehydrogenase SDH1b
    NP_012490.1
    • Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog, SDH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      356024..357928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181478.1 → NP_012490.1  TPA: succinate dehydrogenase SDH1b [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012490.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWD9, P47052
      UniProtKB/TrEMBL
      B3LQ67, C7GSR5, G2WGX3, N1P369
      Conserved Domains (1) summary
      PTZ00139
      Location:5 → 634
      PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47052.1

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