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    VPH2 Vph2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853741, updated on 29-Jun-2024

    Summary

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    Gene symbol
    VPH2
    Gene description
    Vph2p
    Primary source
    FungiDB:YKL119C
    Locus tag
    YKL119C
    See related
    SGD:S000001602; AllianceGenome:SGD:S000001602; VEuPathDB:YKL119C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CLS10; VMA12
    Summary
    Involved in vacuolar acidification and vacuolar proton-transporting V-type ATPase complex assembly. Located in endoplasmic reticulum membrane. Part of Vma12-Vma22 assembly complex. Used to study congenital disorder of glycosylation type IIp. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See VPH2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (218570..219217, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Dgr2p Neighboring gene Oac1p Neighboring gene tRNA-Ala Neighboring gene Hsp90 cochaperone SBA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The VPH2 gene encodes a 25 kDa protein required for activity of the yeast vacuolar H(+)-ATPase. Bachhawat AK, et al. Yeast, 1993 Feb. PMID 8465604
    2. Placing a disrupted degradation motif at the C terminus of proteasome substrates attenuates degradation without impairing ubiquitylation. Alfassy OS, et al. J Biol Chem, 2013 May 3. PMID 23519465, Free PMC Article
    3. VMA12 encodes a yeast endoplasmic reticulum protein required for vacuolar H+-ATPase assembly. Jackson DD, et al. J Biol Chem, 1997 Oct 10. PMID 9325326
    4. VMA12 is essential for assembly of the vacuolar H(+)-ATPase subunits onto the vacuolar membrane in Saccharomyces cerevisiae. Hirata R, et al. J Biol Chem, 1993 Jan 15. PMID 8419376
    5. Vma22p is a novel endoplasmic reticulum-associated protein required for assembly of the yeast vacuolar H(+)-ATPase complex. Hill KJ, et al. J Biol Chem, 1995 Sep 22. PMID 7673216

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Vma12-Vma22 assembly complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vph2p
    NP_012803.1
    • Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      218570..219217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179685.1 → NP_012803.1  TPA: Vph2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012803.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXH1, P32341
      UniProtKB/TrEMBL
      A0A8H4BY28, A6ZZK0, G2WHR7, N1P0S1
      Conserved Domains (1) summary
      pfam11712
      Location:64 → 196
      Vma12; Endoplasmic reticulum-based factor for assembly of V-ATPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32341.1

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