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    RLP24 ATPase-activating ribosome biosynthesis protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850695, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RLP24
    Gene description
    ATPase-activating ribosome biosynthesis protein
    Primary source
    FungiDB:YLR009W
    Locus tag
    YLR009W
    See related
    SGD:S000003999; AllianceGenome:SGD:S000003999; VEuPathDB:YLR009W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATPase activator activity. Involved in assembly of large subunit precursor of preribosome and ribosomal large subunit biogenesis. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human RSL24D1 (ribosomal L24 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RLP24 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (166537..167136)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Smc5-Smc6 complex subunit NSE1 Neighboring gene Pam18p Neighboring gene Ten1p Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers. Klingauf-Nerurkar P, et al. Elife, 2020 Jan 7. PMID 31909713, Free PMC Article
    2. Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1. Pertschy B, et al. Mol Cell Biol, 2007 Oct. PMID 17646390, Free PMC Article
    3. Integrity of the P-site is probed during maturation of the 60S ribosomal subunit. Bussiere C, et al. J Cell Biol, 2012 Jun 11. PMID 22689654, Free PMC Article
    4. Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs. Lebreton A, et al. J Biol Chem, 2006 Sep 15. PMID 16861225
    5. Functional redundancy of yeast proteins Reh1 and Rei1 in cytoplasmic 60S subunit maturation. Parnell KM, et al. Mol Cell Biol, 2009 Jul. PMID 19433447, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in assembly of large subunit precursor of preribosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATPase-activating ribosome biosynthesis protein
    NP_013109.1
    • Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      166537..167136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181896.1 → NP_013109.1  TPA: ATPase-activating ribosome biosynthesis protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY11, Q07915
      UniProtKB/TrEMBL
      A0A6A5PUP3, A7A0R4, B3LSY2, B5VMV1, C7GPE9, C8ZCY1, G2WIK3, N1NYZ6
      Conserved Domains (1) summary
      pfam01246
      Location:2 → 64
      Ribosomal_L24e; Ribosomal protein L24e
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07915.1

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