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    CTR3 high-affinity Cu transporter CTR3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851129, updated on 1-Aug-2024

    Summary

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    Gene symbol
    CTR3
    Gene description
    high-affinity Cu transporter CTR3
    Primary source
    FungiDB:YLR411W
    Locus tag
    YLR411W
    See related
    SGD:S000004403; AllianceGenome:SGD:S000004403; VEuPathDB:YLR411W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables copper ion transmembrane transporter activity. Involved in copper ion import. Is integral component of plasma membrane. Orthologous to human SLC31A1 (solute carrier family 31 member 1) and SLC31A2 (solute carrier family 31 member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CTR3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (947253..947978)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate kinase VIP1 Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene Ber1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tryptophan scanning analysis of the membrane domain of CTR-copper transporters. De Feo CJ, et al. J Membr Biol, 2010 Apr. PMID 20224886, Free PMC Article
    2. Characterization of the Saccharomyces cerevisiae high affinity copper transporter Ctr3. Pena MM, et al. J Biol Chem, 2000 Oct 27. PMID 10924521
    3. A widespread transposable element masks expression of a yeast copper transport gene. Knight SA, et al. Genes Dev, 1996 Aug 1. PMID 8756349
    4. Eukaryotic CTR copper uptake transporters require two faces of the third transmembrane domain for helix packing, oligomerization, and function. Aller SG, et al. J Biol Chem, 2004 Dec 17. PMID 15385536, Free PMC Article
    5. The Candida albicans CTR1 gene encodes a functional copper transporter. Marvin ME, et al. Microbiology (Reading), 2003 Jun. PMID 12777486

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in copper ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high-affinity Cu transporter CTR3
    NP_013515.3
    • High-affinity copper transporter of the plasma membrane; acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      947253..947978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182299.3 → NP_013515.3  TPA: high-affinity Cu transporter CTR3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013515.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ47, Q06686
      UniProtKB/TrEMBL
      A7A1T4, B3RHS2, B5VNU4, C8ZE20
      Conserved Domains (1) summary
      pfam04145
      Location:20 → 210
      Ctr; Ctr copper transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06686.1

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