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    TUB3 alpha-tubulin TUB3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854915, updated on 26-Jun-2024

    Summary

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    Gene symbol
    TUB3
    Gene description
    alpha-tubulin TUB3
    Primary source
    FungiDB:YML124C
    Locus tag
    YML124C
    See related
    SGD:S000004593; AllianceGenome:SGD:S000004593; VEuPathDB:YML124C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of cytoskeleton. Predicted to be involved in several processes, including microtubule cytoskeleton organization; nuclear division; and nuclear migration by microtubule mediated pushing forces. Located in spindle. Part of tubulin complex. Used to study several diseases, including Alzheimer's disease; leukemia; lissencephaly; lung carcinoma; and osteoblastoma. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 3; amyotrophic lateral sclerosis type 22; keratoconus; lissencephaly (multiple); and visual epilepsy. Orthologous to several human genes including EHHADH (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase); TUBA1A (tubulin alpha 1a); and TUBA1B (tubulin alpha 1b). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TUB3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    2
    Sequence:
    Chromosome: XIII; NC_001145.3 (22048..23683, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene hydroxymethylglutaryl-CoA synthase Neighboring gene cytochrome-b5 reductase Neighboring gene ncRNA Neighboring gene phosphate transporter PHO84 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex. Carminati JL, et al. J Cell Biol, 1997 Aug 11. PMID 9245791, Free PMC Article
    2. Functions of microtubules in the Saccharomyces cerevisiae cell cycle. Jacobs CW, et al. J Cell Biol, 1988 Oct. PMID 3049620, Free PMC Article
    3. The two alpha-tubulin isotypes in budding yeast have opposing effects on microtubule dynamics in vitro. Bode CJ, et al. EMBO Rep, 2003 Jan. PMID 12524528, Free PMC Article
    4. The polarity and dynamics of microtubule assembly in the budding yeast Saccharomyces cerevisiae. Maddox PS, et al. Nat Cell Biol, 2000 Jan. PMID 10620805, Free PMC Article
    5. The Saccharomyces cerevisiae kinesin-related motor Kar3p acts at preanaphase spindle poles to limit the number and length of cytoplasmic microtubules. Saunders W, et al. J Cell Biol, 1997 Apr 21. PMID 9128252, Free PMC Article

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homologous chromosome segregation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration along microtubule IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in nuclear migration by microtubule mediated pushing forces IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle HDA PubMed 
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tubulin complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-tubulin TUB3
    NP_013582.1
    • Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      22048..23683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182487.1 → NP_013582.1  TPA: alpha-tubulin TUB3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013582.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0G1, P09734
      UniProtKB/TrEMBL
      A6ZLU1, B3LLD6, C8ZE78, G2WJT3, N1NZC7
      Conserved Domains (1) summary
      cd02186
      Location:2 → 436
      alpha_tubulin; The alpha-tubulin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09734.1

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