CDC31 centrin [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CDC31
Gene description: centrin
Primary source: FungiDB:YOR257W
Locus tag: YOR257W
See related: SGD:S000005783; AllianceGenome:SGD:S000005783; VEuPathDB:YOR257W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DSK1
Summary: Predicted to enable calcium ion binding activity and microtubule binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of kinase activity; and spindle pole body duplication. Located in half bridge of spindle pole body. Part of transcription export complex 2. Orthologous to human CETN3 (centrin 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CDC31 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (811008..811493)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although it is unclear how Cdc31 contributes to so many unrelated mechanisms, the study proposes that by controlling spindle pole body duplication Centrin proteins might link the cellular responses to DNA damage, oxidative load and proteotoxic stresses to growth control.
Title: A role for Saccharomyces cerevisiae Centrin (Cdc31) in mitochondrial function and biogenesis.
The Vps13p-Cdc31p complex is directly required for transgolgi network late endosome transport and TGN homotypic fusion.
Title: The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion.
results provide insight into how newly synthesized transcripts are efficiently transferred from TREX-2 to the principal mRNA export factor, and they reveal how Sem1 stabilizes PCI domain-containing proteins and promotes complex assembly
Title: Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex.
Thp1-Sac3-Sus1-Cdc31, together with THO/TREX, define a specific pathway connecting transcription elongation with export via an RNA-dependent dynamic process
Title: The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.
Cdc31 is a novel regulator of protein degradation.
Title: Centrin/Cdc31 is a novel regulator of protein degradation.
Cdc31 bound with Sfi1 in a complex have a role in spindle pole body duplication.
Title: Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle pole body duplication	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle pole body duplication	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in half bridge of spindle pole body	IBA Inferred from Biological aspect of Ancestor more info
located_in half bridge of spindle pole body	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle pole body	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle pole body	IEA Inferred from Electronic Annotation more info
part_of transcription export complex 2	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: centrin

NP_014900.3

Calcium-binding component of the spindle pole body (SPB) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation