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    FSH3 putative serine hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854454, updated on 29-Jun-2024

    Summary

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    Gene symbol
    FSH3
    Gene description
    putative serine hydrolase
    Primary source
    FungiDB:YOR280C
    Locus tag
    YOR280C
    See related
    SGD:S000005806; AllianceGenome:SGD:S000005806; VEuPathDB:YOR280C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Predicted to be active in cytoplasm and nucleus. Orthologous to human OVCA2 (OVCA2 serine hydrolase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FSH3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (844992..845792, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uroporphyrinogen-III synthase HEM4 Neighboring gene Rfm1p Neighboring gene Plp2p Neighboring gene phosphoglycerate mutase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human OVCA2 and its homolog FSH3-induced apoptosis in Saccharomyces cerevisiae. Gowsalya R, et al. Curr Genet, 2021 Aug. PMID 33715035
    2. Determining the targeting specificity of the selective peroxisomal targeting factor Pex9. Yifrach E, et al. Biol Chem, 2023 Feb 23. PMID 36279206
    3. FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae. Gowsalya R, et al. FEMS Yeast Res, 2019 May 1. PMID 30776074
    4. Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast. Baxter SM, et al. Mol Cell Proteomics, 2004 Mar. PMID 14645503
    5. Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae. Zaim J, et al. J Biol Chem, 2005 Jan 7. PMID 15494396

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human OVCA2 and its homolog FSH3-induced apoptosis in Saccharomyces cerevisiae.
      Title: Human OVCA2 and its homolog FSH3-induced apoptosis in Saccharomyces cerevisiae.
    2. FSH3 induced apoptosis of yeast in a NUC1 dependent manner.
      Title: FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative serine hydrolase
    NP_014923.1
    • Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; localizes to cytosol and peroxisomes; similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      844992..845792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183699.1 → NP_014923.1  TPA: putative serine hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014923.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2X9, Q99369
      UniProtKB/TrEMBL
      A0A8H4F8U0, A6ZPB6, B3LJU5, B5VSG0, C7GWB1, C8ZH30, G2WNE7, N1NVY1
      Conserved Domains (1) summary
      pfam03959
      Location:2 → 220
      FSH1; Serine hydrolase (FSH1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99369.1

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