RDL2 thiosulfate sulfurtransferase RDL2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: RDL2
Gene description: thiosulfate sulfurtransferase RDL2
Primary source: FungiDB:YOR286W
Locus tag: YOR286W
See related: SGD:S000005812; AllianceGenome:SGD:S000005812; VEuPathDB:YOR286W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AIM42
Summary: Enables thiosulfate sulfurtransferase activity. Located in mitochondrion. Orthologous to several human genes including TSTD1 (thiosulfate sulfurtransferase like domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RDL2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (850280..850729)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rhodanese Rdl2 produces reactive sulfur species to protect mitochondria from reactive oxygen species.
Title: Rhodanese Rdl2 produces reactive sulfur species to protect mitochondria from reactive oxygen species.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables thiosulfate sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiosulfate sulfurtransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables thiosulfate sulfurtransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in sulfur compound metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thiosulfate sulfurtransferase RDL2

NP_014929.3

EC 2.8.1.1

Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

850280..850729

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183705.3 → NP_014929.3 TPA: thiosulfate sulfurtransferase RDL2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014929.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2Y4, Q08742

UniProtKB/TrEMBL

A0A6A5Q322, A6ZPC1, B3LJV0, C7GWA6, C8ZH36, G2WNF2, N1NVY3

Conserved Domains (1) summary

cd01519
Location:33 → 139

RHOD_HSP67B2; Member of the Rhodanese Homology Domain superfamily. This CD includes the heat shock protein 67B2 of Drosophila melanogaster and other similar proteins, many of which are uncharacterized.