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    RPL21B ribosomal 60S subunit protein L21B [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856026, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RPL21B
    Gene description
    ribosomal 60S subunit protein L21B
    Primary source
    FungiDB:YPL079W
    Locus tag
    YPL079W
    See related
    SGD:S000006000; AllianceGenome:SGD:S000006000; VEuPathDB:YPL079W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in hypotrichosis 12. Orthologous to human RPL21 (ribosomal protein L21). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPL21B in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    2
    Sequence:
    Chromosome: XVI; NC_001148.4 (406636..407539)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S9A Neighboring gene uncharacterized protein Neighboring gene F1F0 ATP synthase subunit 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Innate immunity to yeast prions: Btn2p and Cur1p curing of the [URE3] prion is prevented by 60S ribosomal protein deficiency or ubiquitin/proteasome system overactivity. Bezsonov EE, et al. Genetics, 2021 Apr 15. PMID 33857305, Free PMC Article
    2. Genome-wide association across Saccharomyces cerevisiae strains reveals substantial variation in underlying gene requirements for toxin tolerance. Sardi M, et al. PLoS Genet, 2018 Feb. PMID 29474395, Free PMC Article
    3. Sensitivity of yeast to lithium chloride connects the activity of YTA6 and YPR096C to translation of structured mRNAs. Hajikarimlou M, et al. PLoS One, 2020. PMID 32639961, Free PMC Article
    4. Proteomic Analysis Identifies Ribosome Reduction as an Effective Proteotoxic Stress Response. Guerra-Moreno A, et al. J Biol Chem, 2015 Dec 11. PMID 26491016, Free PMC Article
    5. Plant-derived antifungal agent poacic acid targets β-1,3-glucan. Piotrowski JS, et al. Proc Natl Acad Sci U S A, 2015 Mar 24. PMID 25775513, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L21B
    NP_015246.1
    • Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      406636..407539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183893.1 → NP_015246.1  TPA: ribosomal 60S subunit protein L21B [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015246.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3T7, Q12672
      UniProtKB/TrEMBL
      A6ZWH1, B3LKZ1, C8ZIV1, G2WPA2, N1NVX6
      Conserved Domains (1) summary
      PTZ00189
      Location:1 → 157
      PTZ00189; 60S ribosomal protein L21; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12672.1

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