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    RPF2 rRNA-binding ribosome biosynthesis protein RPF2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853956, updated on 1-Aug-2024

    Summary

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    Gene symbol
    RPF2
    Gene description
    rRNA-binding ribosome biosynthesis protein RPF2
    Primary source
    FungiDB:YKR081C
    Locus tag
    YKR081C
    See related
    SGD:S000001789; AllianceGenome:SGD:S000001789; VEuPathDB:YKR081C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 5S rRNA binding activity and 7S RNA binding activity. Involved in assembly of large subunit precursor of preribosome and ribosome biogenesis. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human RPF2 (ribosome production factor 2 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPF2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (591506..592540, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNase Z Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD(+)) Neighboring gene Nup133p Neighboring gene Dad2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chaperoning 5S RNA assembly. Madru C, et al. Genes Dev, 2015 Jul 1. PMID 26159998, Free PMC Article
    2. Structural and functional analysis of the Rpf2-Rrs1 complex in ribosome biogenesis. Asano N, et al. Nucleic Acids Res, 2015 May 19. PMID 25855814, Free PMC Article
    3. Interactions among Ytm1, Erb1, and Nop7 required for assembly of the Nop7-subcomplex in yeast preribosomes. Tang L, et al. Mol Biol Cell, 2008 Jul. PMID 18448671, Free PMC Article
    4. Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. Morita D, et al. J Biol Chem, 2002 Aug 9. PMID 12048200
    5. Assembly factors Rpf2 and Rrs1 recruit 5S rRNA and ribosomal proteins rpL5 and rpL11 into nascent ribosomes. Zhang J, et al. Genes Dev, 2007 Oct 15. PMID 17938242, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5S rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5S rRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 7S RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in assembly of large subunit precursor of preribosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 

    General protein information

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    Preferred Names
    rRNA-binding ribosome biosynthesis protein RPF2
    NP_013007.1
    • Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      591506..592540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179871.1 → NP_013007.1  TPA: rRNA-binding ribosome biosynthesis protein RPF2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013007.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXE1, P36160
      UniProtKB/TrEMBL
      A7A040, B5VMM5, C7GXC9, C8ZCP2, G2WIA8, N1P0K2
      Conserved Domains (1) summary
      COG5106
      Location:1 → 324
      RPF2; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36160.1

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