cyp8b1.1 cytochrome P450 family 8 subfamily B member 1, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp8b1.1provided by ZNC
Official Full Name: cytochrome P450 family 8 subfamily B member 1, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040808-53
See related: Ensembl:ENSDARG00000053068 AllianceGenome:ZFIN:ZDB-GENE-040808-53
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cyp8b1; zgc:92406; si:ch73-198j8.4
Summary: Predicted to enable sterol 12-alpha-hydroxylase activity. Predicted to act upstream of or within cholesterol metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in intestinal bulb and liver. Orthologous to human CYP8B1 (cytochrome P450 family 8 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (3435888..3437862, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (3604709..3606683, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb67h05 (e-PCR)
- UniSTS:189078

fl10c05.x1 (e-PCR)
- UniSTS:201965

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables sterol 12-alpha-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

Names: cytochrome P450, family 8, subfamily B, polypeptide 1

NP_001003736.1

EC 1.14.14.139

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.