U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RPM2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854883, updated on 11-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RPM2
    Primary source
    SGD:S000004556
    Locus tag
    YML091C
    See related
    AllianceGenome:SGD:S000004556; FungiDB:YML091C; VEuPathDB:YML091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ribonuclease P activity. Involved in several processes, including RNA processing; cytoplasmic translation; and positive regulation of transcription by RNA polymerase II. Located in mitochondrial matrix and nucleus. Part of mitochondrial ribonuclease P complex. [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (87123..90731, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Utp14p Neighboring gene proteasome core particle subunit alpha 2 Neighboring gene ncRNA Neighboring gene SCF ubiquitin ligase complex subunit UFO1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mitochondrial RNase P: the RNA family grows. Martin NC, et al. Nucleic Acids Symp Ser, 1997. PMID 9478201
    2. Yeast mitochondrial RNase P RNA synthesis is altered in an RNase P protein subunit mutant: insights into the biogenesis of a mitochondrial RNA-processing enzyme. Stribinskis V, et al. Mol Cell Biol, 1996 Jul. PMID 8668158, Free PMC Article
    3. A 105-kDa protein is required for yeast mitochondrial RNase P activity. Morales MJ, et al. Proc Natl Acad Sci U S A, 1992 Oct 15. PMID 1409716, Free PMC Article
    4. Rpm2p, a component of yeast mitochondrial RNase P, acts as a transcriptional activator in the nucleus. Stribinskis V, et al. Mol Cell Biol, 2005 Aug. PMID 16024791, Free PMC Article
    5. Rpm2p: separate domains promote tRNA and Rpm1r maturation in Saccharomyces cerevisiae mitochondria. Stribinskis V, et al. Nucleic Acids Res, 2001 Sep 1. PMID 11522833, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rpm2p has a transcriptional activation domain and plays a role in defining the mRNAs for some nucleus-encoded mitochondrial components.
      Title: Rpm2p, a component of yeast mitochondrial RNase P, acts as a transcriptional activator in the nucleus.
    2. Rpm2p appears to function as a coordinator of transcription and mRNA storage/decay in P bodies.
      Title: Rpm2p, a protein subunit of mitochondrial RNase P, physically and genetically interacts with cytoplasmic processing bodies.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonuclease P activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonuclease P activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA processing IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mitochondrial tRNA 5'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA 5'-leader removal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ribonuclease P
    NP_013619.1
    • Protein subunit of mitochondrial RNase P; has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      87123..90731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182450.1 → NP_013619.1  TPA: ribonuclease P [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0J4, Q02773
      UniProtKB/TrEMBL
      G2WJW6
      Conserved Domains (2) summary
      sd00004
      Location:194 → 216
      PPR; PPR repeat [structural motif]
      pfam08579
      Location:163 → 281
      RPM2; Mitochondrial ribonuclease P subunit (RPM2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02773.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools