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    FDC1 putative phenylacrylic acid decarboxylase FDC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852152, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FDC1
    Official Full Name
    putative phenylacrylic acid decarboxylase FDC1
    Primary source
    SGD:S000002947
    Locus tag
    YDR539W
    See related
    AllianceGenome:SGD:S000002947; FungiDB:YDR539W; VEuPathDB:YDR539W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables carboxy-lyase activity. Involved in cinnamic acid catabolic process and ferulate metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See FDC1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1512094..1513605)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene glucose-inactivated glycerol proton symporter STL1 Neighboring gene phenylacrylic acid decarboxylase PAD1 Neighboring gene Irc4p Neighboring gene carbonyl reductase (NADPH-dependent)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploring the substrate scope of ferulic acid decarboxylase (FDC1) from Saccharomyces cerevisiae. Nagy EZA, et al. Sci Rep, 2019 Jan 24. PMID 30679592, Free PMC Article
    2. Reducing phenolic off-flavors through CRISPR-based gene editing of the FDC1 gene in Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid lager beer yeasts. Mertens S, et al. PLoS One, 2019. PMID 30625138, Free PMC Article
    3. PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae. Mukai N, et al. J Biosci Bioeng, 2010 Jun. PMID 20471595
    4. Single nucleotide polymorphisms of PAD1 and FDC1 show a positive relationship with ferulic acid decarboxylation ability among industrial yeasts used in alcoholic beverage production. Mukai N, et al. J Biosci Bioeng, 2014 Jul. PMID 24507903
    5. Overexpression of PAD1 and FDC1 results in significant cinnamic acid decarboxylase activity in Saccharomyces cerevisiae. Richard P, et al. AMB Express, 2015. PMID 25852989, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. substrate scope of ferulic acid decarboxylase (FDC1) from Saccharomyces cerevisiae
      Title: Exploring the substrate scope of ferulic acid decarboxylase (FDC1) from Saccharomyces cerevisiae.
    2. PAD1 synthesizes a cofactor required by FDC (ferulic acid decarboxylase) for decarboxylase activity.
      Title: Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by ferulic acid decarboxylase and 4-hydroxy-3-polyprenylbenzoic acid decarboxylase.
    3. study presents 3-dimensional structure of FDC1; crystallization with a decarboxylated reaction product identifies a large apolar cavity as the active site and suggests a catalytic mechanism for the nonoxidative decarboxylation reaction of aromatic substrates
      Title: Structure and Mechanism of Ferulic Acid Decarboxylase (FDC1) from Saccharomyces cerevisiae.
    4. examination of the contribution of the FDC1 (ferulic acid decarboxylase, YDR539W) gene to the decarboxylation of phenylacrylic acid using gene disruptants and the corresponding transformants in which the disrupted genes were recovered.
      Title: PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxy-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxy-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cinnamic acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cinnamic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cinnamic acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ferulate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ferulate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ferulate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ferulate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative phenylacrylic acid decarboxylase FDC1
    NP_010828.1
    • Ferulic acid decarboxylase; involved in the decarboxylation of aromatic carboxylic acids such as phenylacrylic (cinnamic) acid, ferulic acid and coumaric acid and formation of the corresponding vinyl derivatives; overexpression of both Pad1p and Fdc1p increases decarboxylase activity due to the Pad1p-catalyzed formation of a diffusible cofactor required for Fdc1p activity; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm in an HTP study

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1512094..1513605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180847.1 → NP_010828.1  TPA: putative phenylacrylic acid decarboxylase FDC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010828.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTF8, Q03034
      UniProtKB/TrEMBL
      A6ZZC4, B2NII1, B3LFD4, C7GST3, C8Z698, E9P8F1, E9P8F2
      Conserved Domains (1) summary
      TIGR00148
      Location:10 → 463
      TIGR00148; UbiD family decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03034.1

    Gene LinkOut

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