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    COA2 Coa2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 1466518, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COA2
    Official Full Name
    Coa2p
    Primary source
    SGD:S000028527
    Locus tag
    YPL189C-A
    See related
    AllianceGenome:SGD:S000028527; FungiDB:YPL189C-A; VEuPathDB:YPL189C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See COA2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (188307..188513, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ubiquitinyl hydrolase 1 Neighboring gene Nab3p Neighboring gene putative O-acyltransferase Neighboring gene NADH kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oligomerization of heme o synthase in cytochrome oxidase biogenesis is mediated by cytochrome oxidase assembly factor Coa2. Khalimonchuk O, et al. J Biol Chem, 2012 Aug 3. PMID 22669974, Free PMC Article
    2. Selective Oma1 protease-mediated proteolysis of Cox1 subunit of cytochrome oxidase in assembly mutants. Khalimonchuk O, et al. J Biol Chem, 2012 Mar 2. PMID 22219186, Free PMC Article
    3. Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeast. Bohovych I, et al. J Biol Chem, 2014 May 9. PMID 24648523, Free PMC Article
    4. Analysis of Leigh syndrome mutations in the yeast SURF1 homolog reveals a new member of the cytochrome oxidase assembly factor family. Bestwick M, et al. Mol Cell Biol, 2010 Sep. PMID 20624914, Free PMC Article
    5. Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1. Pierrel F, et al. Mol Cell Biol, 2008 Aug. PMID 18541668, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CcO assembly factor Coa2 appears important in coupling the presence of newly synthesized Cox1 to Cox10 oligomerization
      Title: Oligomerization of heme o synthase in cytochrome oxidase biogenesis is mediated by cytochrome oxidase assembly factor Coa2.
    2. Coa2 appears to impart stability to the oligomeric wild-type Cox10 complex involved in Cox1 hemylation.
      Title: The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10.
    3. The matrix-localized Coa2 protein may aid in stabilizing an early Cox1 intermediate containing the nuclear subunits Cox5a and Cox6.
      Title: Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial cytochrome c oxidase assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Coa2p
    NP_878179.1
    • Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      188307..188513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184537.1 → NP_878179.1  TPA: Coa2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_878179.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3H9, Q3E823
      UniProtKB/TrEMBL
      A6ZW64, B3LKN9, C7GJD8, C8ZII9, G2WNZ4, N1NVN7
      Conserved Domains (1) summary
      pfam17051
      Location:1 → 67
      COA2; Cytochrome C oxidase assembly factor 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E823.1

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